Evidence mapPaperPMID 40833403Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.

Natalie Blaum, Tina Ghelani, Torsten W B Götz, Keagan S Chronister, Mercedes Bengochea, Livia Ceresnova, Christian F Christensen, Thiago C Moulin, Hanna Kern, Ulrich Thomas and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Munc13-1 couples DAG and CaScience advances · 2026
    Article
  3. Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Natalie Blaum *Molecular and Theoretical Neuroscience, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Tina Ghelani *Molecular and Theoretical Neuroscience, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin 13125, Germany.
Torsten W B Götz *Molecular and Theoretical Neuroscience, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin 13125, Germany.
Keagan S Chronister *Molecular and Theoretical Neuroscience, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Mercedes BengocheaMolecular and Theoretical Neuroscience, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Livia CeresnovaMolecular and Theoretical Neuroscience, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Christian F ChristensenMolecular and Theoretical Neuroscience, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Thiago C MoulinMolecular and Theoretical Neuroscience, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Hanna KernFunctional Neurobiology, Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, Mainz 55128, Germany.
Ulrich ThomasDepartment of Cellular Neurobiology, Leibniz Institute for Neurobiology, Magdeburg 39118, Germany.ORCID 0000-0002-4372-8611
Martin HeineFunctional Neurobiology, Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, Mainz 55128, Germany.
Stephan J SigristInstitute for Biology and Genetics, Freie Universität Berlin, Berlin 14195, Germany.ORCID 0000-0002-1698-5815
Alexander M WalterMolecular and Theoretical Neuroscience, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.ORCID 0000-0001-5646-4750

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · TRUSTEES OF INDIANA UNIVERSITY · 2025 to 2025
$1.7M
Deutsche Forschungsgemeinschaft (DFG) 261020751Deutsche Forschungsgemeinschaft (DFG) 278001972Deutsche Forschungsgemeinschaft (DFG) HE3604/11-1EC | European Research Council (ERC) 101045054NIH HHS P40 OD018537Novo Nordisk Fonden (NNF) NNF19OC0056047
6 · The paper itself

Abstract

Neuromodulators control mood, arousal, and behavior by inducing synaptic plasticity via G-protein-coupled receptors. While long-term presynaptic potentiation requires structural changes, mechanisms enabling potentiation within minutes remain unclear. Using the

Indexed as

DiglyceridesDrosophila ProteinsNerve Tissue ProteinsPresynaptic TerminalsAnimalsDrosophila melanogasterNeuromuscular JunctionNeuronal PlasticityOctopamineSignal TransductionSynaptic TransmissionDiglyceridesDrosophila ProteinsNerve Tissue ProteinsOctopamineG-protein- coupled receptorsMunc13Neuromodulationneurotransmitter releasesynaptic plasticity

Identifiers

PMID40833403
PMCPMC12403152

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.