ArticleAnnals of surgical oncology2026
Impact of Social Vulnerability and Allostatic Load on Postoperative Outcomes.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Review
- ASO Author Reflections: Impact of Social Vulnerability and Allostatic Load on Postoperative Outcomes.Annals of surgical oncology · 2026Article
- Beyond iodine nutrition: socioeconomic patterns independently drive thyroid disease risk in pregnant women in Xinjiang.Frontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe sought to investigate the association between allostatic load (AL), social vulnerability, and postoperative outcomes following hepatopancreatobiliary (HPB) cancer surgery.
methodsIndividuals who underwent HPB surgery were identified using the Epic Cosmos database. AL was calculated based on 10 biomarkers across four physiological systems: cardiovascular, metabolic, renal, and immune. Multivariable regression models were used to examine the association between AL, postoperative outcomes, and failure to rescue (FTR).
resultsAmong 34,253 individuals, mean patient age was 71 years (interquartile range 63-78). Approximately half of patients were male (n = 18,045, 52.7%) and had a high Charlson Comorbidity Index (CCI) score (CCI >2; n = 29,246, 85.4%). The most common cancer site was the pancreas (n = 21,402, 62.5%), followed by the liver (n = 8451, 24.7%) and the biliary tract (n = 4400, 12.8%). Overall, 13.8% (n = 4717) of patients had high AL. On multivariable analysis, the risk of allostasis increased stepwise with higher social vulnerability (reference: low; medium: odds ratio [OR] 1.11, 95% confidence interval [CI] 1.04-1.19; high: OR 1.17, 95% CI 1.11-1.17). Moreover, high AL was associated with a 44% increased risk of Clavien-Dindo grade IV complications (OR 1.44, 95% CI 1.36-1.54) and an 85% increased risk of FTR (OR 1.85, 95% CI 1.60-2.13). In addition, the risk of 30-day mortality was approximately twofold higher with elevated AL (OR 1.92, 95% CI 1.70-2.19).
conclusionIndividuals residing in socially vulnerable areas experience socioeconomic stressors that contribute to long-term physiological damage, resulting in worse outcomes following surgery.
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