Evidence map›Paper›PMID 40834211›Full record

ReviewArquivos brasileiros de cardiologia2025

Medical Reversals, Spins and Divergent Results in Cardiology Trials.

José Nunes de Alencar, Bruno Robalinho Cavalcanti, Guilherme Augusto Teodoro Athayde

Abstract readReview
In one paragraph

Review in Arquivos brasileiros de cardiologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

José Nunes de AlencarInstituto Dante Pazzanese de Cardiologia, São Paulo, SP - Brasil.ORCID 0000-0002-3835-6067
Bruno Robalinho CavalcantiUniversidade Federal de Campina Grande, Campina Grande, PB - Brasil.ORCID 0000-0003-2495-3466
Guilherme Augusto Teodoro AthaydeDom José Maria Pires Metropolitan Hospital, João Pessoa, PB - Brasil.ORCID 0000-0002-4112-3600

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular medicine has witnessed remarkable breakthroughs, yet even highly regarded interventions can be undermined by flawed reasoning, excessive mechanistic assumptions, and the selective reporting of data. This article examines crucial pitfalls in contemporary cardiology, such as medical reversals, the impact of spin, and how bayesian methods can offer greater clarity in evaluating evidence, as they integrate prior knowledge with new data to generate more probabilistic, context-driven conclusions. This review advocates for a measured, critical approach to research appraisal, cautioning cardiologists against uncritically accepting trial conclusions at face value. Adopting this vigilant stance will help ensure that emerging therapies and interventions genuinely advance patient outcomes, guiding physicians toward more credible, transparent, and beneficial strategies in the ever-evolving field of cardiovascular medicine. Such vigilance is important to preserve the integrity of scientific inquiry and meaningful progress in patient care. This approach promotes reliability of published data.

Indexed as

CardiologyCardiovascular DiseasesClinical Trials as TopicBayes TheoremEvidence-Based MedicineHumansReproducibility of ResultsResearch Design

Identifiers

PMID40834211
PMCPMC12695093

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.