Evidence map›Paper›PMID 40834435›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2-Dependent Mechanisms.

Ambra Da Ros, Maddalena Benetton, Giulia Borella, Giorgia Longo, Giulia Borile, Alice Cani, Diego Lopez-Pigozzi, Mario Bortolozzi, Silvia Bresolin, Claudia Tregnago and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ambra Da RosDepartment of Women's and Children's Health, Onco-Hematology lab and clinic, University of Padova, Padova, 35128, Italy.
Maddalena BenettonDepartment of Women's and Children's Health, Onco-Hematology lab and clinic, University of Padova, Padova, 35128, Italy.
Giulia BorellaDepartment of Women's and Children's Health, Onco-Hematology lab and clinic, University of Padova, Padova, 35128, Italy.
Giorgia LongoDepartment of Women's and Children's Health, Onco-Hematology lab and clinic, University of Padova, Padova, 35128, Italy.
Giulia BorileFoundation Istituto Ricerca Pediatrica Città della Speranza, Padova, 35127, Italy.
Alice CaniDepartment of Women's and Children's Health, Onco-Hematology lab and clinic, University of Padova, Padova, 35128, Italy.
Diego Lopez-PigozziDepartment of Physics and Astronomy "G. Galilei", University of Padova, Padova, 35121, Italy.
Mario BortolozziDepartment of Physics and Astronomy "G. Galilei", University of Padova, Padova, 35121, Italy.
Silvia BresolinFoundation Istituto Ricerca Pediatrica Città della Speranza, Padova, 35127, Italy.
Claudia TregnagoDepartment of Women's and Children's Health, Onco-Hematology lab and clinic, University of Padova, Padova, 35128, Italy.
Franco LocatelliDepartment of Pediatric Hematology and Oncology, IRCCS, Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, 00165, Italy.
Martina PigazziDepartment of Women's and Children's Health, Onco-Hematology lab and clinic, University of Padova, Padova, 35128, Italy.ORCID https://orcid.org/0000-0002-4793-5263

Funding

AssociazioneItaliana Contro le Leucemie-linfomi e mieloma (AIL)-Treviso sectionFondazione AIRC 2017ID20562Istituto di Ricerca PediatricaMinistero dell'Università e della Ricerca PRIN2020
6 · The paper itself

Abstract

Mesenchymal stromal cells (MSCs) are key components of the tumor microenvironment (TME), influencing leukemia progression through poorly understood mechanisms. Here, the bioelectrical properties of MSCs derived from pediatric acute myeloid leukemia (AML) patients (AML-MSCs) are investigated, identifying a significant depolarization of their resting voltage membrane potential (V

Indexed as

Bone MarrowCalcium Channels, L-TypeLeukemia, Myeloid, AcuteMesenchymal Stem CellsChildHumansMembrane PotentialsStem Cell NicheTumor MicroenvironmentCACNA1C protein, humanCalcium Channels, L-TypeL-type calcium channel alpha(1C)acute myeloid leukemiabioelectricitymesenchymal stromal cellstumor microenvironmentvoltage membrane potential

Identifiers

PMID40834435
PMCPMC12533209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.