Evidence map›Paper›PMID 40835441›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

IGFBP2-Ceramide Pathway Mediates Divergent Myelin Breakdown in the PNS and CNS Following Injury.

Suchen Ma, Xinman Fu, Jinmeng Lyu, Weilin Guo, Jieni Wang, Jingrui Li, Zhengxin Ying

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suchen MaState Key Laboratory of Agrobiotechnology, Department of Nutrition and Health, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Xinman FuState Key Laboratory of Agrobiotechnology, Department of Nutrition and Health, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Jinmeng LyuState Key Laboratory of Agrobiotechnology, Department of Nutrition and Health, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Weilin GuoState Key Laboratory of Agrobiotechnology, Department of Nutrition and Health, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Jieni WangState Key Laboratory of Microbial Technology, Shandong University, Qingdao 250100, Shandong, China.
Jingrui LiCollege of Biological Sciences, China Agricultural University, Beijing 100193, China.
Zhengxin YingState Key Laboratory of Agrobiotechnology, Department of Nutrition and Health, College of Biological Sciences, China Agricultural University, Beijing 100193, China yingzhengxin@cau.edu.cn.ORCID 0000-0003-0948-4948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following injury, the peripheral nervous system (PNS) exhibits remarkable regenerative capacity, whereas the central nervous system (CNS) has limited regenerative potential. This difference is partially attributed to distinct postinjury myelin breakdown. However, the underlying mechanisms driving this disparity remain unclear. By comparing the expression profiles of injured peripheral and central nerves in adult male and female C57BL/6J mice, we identified insulin-like growth factor-binding protein 2 (IGFBP2) as a key regulator that determines the differences in myelin breakdown between the injured PNS and CNS. Schwann cell-derived IGFBP2 in the injured PNS promotes myelin breakdown and facilitates axonal regeneration. Furthermore, through lipidomics, we identify ceramide, a sphingolipid regulated by ceramide synthase 6 in injured nerves, as playing a critical role in IGFBP2-mediated myelin breakdown. Conversely, minimal IGFBP2 expression is observed in the injured CNS, contributing to the limited myelin breakdown and axon regeneration in injured CNS. These findings provide insights into the divergent regenerative potential of the PNS and CNS and unveil IGFBP2 and ceramide as promising targets for promoting CNS regeneration after injury.

Indexed as

Central Nervous SystemCeramidesInsulin-Like Growth Factor Binding Protein 2Myelin SheathAnimalsFemaleMaleMiceMice, Inbred C57BLNerve RegenerationPeripheral Nervous SystemSignal TransductionCeramidesInsulin-Like Growth Factor Binding Protein 2

Identifiers

PMID40835441
PMCPMC12548708

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.