Observational studyInternal medicine (Tokyo, Japan)2026
Efficacy and Safety of Dotinurad in Patients with Advanced Chronic Kidney Disease.
Observational study in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effect of dotinurad versus febuxostat on the one-year eGFR slope in CKD patients with hyperuricemia: a retrospective cohort study.BMC nephrology · 2026Article
- Effect of Dotinurad on Uric Acid and Hepatorenal Parameters in Steatotic Liver Disease: A Pilot Study in Japanese Patients.Biomedicines · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective Hyperuricemia is associated with cardiovascular disease and chronic kidney disease (CKD). Dotinurad is a new uricosuric drug that has not been evaluated in clinical trials in patients with advanced CKD (CKD G3b-G5). This study evaluated the efficacy of dotinurad in lowering serum uric acid levels, its safety profile, and its effect on the renal function in hyperuricemic patients with CKD G3b to G5. Methods This was a single-center retrospective observational study. Patients Fourteen patients with CKD G3b to G5 who received dotinurad in the outpatient clinic and for whom data were available for six months before and after treatment were enrolled in this study. Serum uric acid levels six months after treatment and the estimated glomerular filtration rate (eGFR) six months before and after treatment were evaluated. Results Serum uric acid levels significantly decreased from 8.2 (8.0-8.5) mg/dL to 6.2 (5.9-7.2) mg/dL six months after treatment (p<0.01). The eGFR was 25.4 (19.4-40.6) mL/min/1.73 m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.