Evidence map›Paper›PMID 40835488›Full record

ArticleEBioMedicine2025

Steroid hormone biosynthesis and dietary related metabolites associated with excessive daytime sleepiness.

Tariq Faquih, Kaitlin S Potts, Pavithra Nagarajan, Bing Yu, Robert Kaplan, Carmen R Isasi, Qibin Qi, Kent D Taylor, Peter Y Liu, Satu J Strausz and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Lifestyles, metabolome and diabetic kidney disease: a cohort study.QJM : monthly journal of the Association of Physicians · 2026
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Tariq FaquihDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute, Cambridge, MA, USA; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Sleep Medicine, Harvard University Medical School, Boston, MA, USA. Electronic address: tfaquih@bwh.harvard.edu.
Kaitlin S PottsDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard University Medical School, Boston, MA, USA.
Pavithra NagarajanDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard University Medical School, Boston, MA, USA.
Bing YuDepartment of Epidemiology, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Robert KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Qibin QiDepartment of Epidemiology, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Kent D TaylorDepartment of Paediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Centre, Torrance, CA, USA.
Peter Y LiuDepartment of Paediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Centre, Torrance, CA, USA.
Satu J StrauszBroad Institute, Cambridge, MA, USA; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland; Department of Oral and Maxillofacial Diseases, Head and Neck Center, Cleft Palate and Craniofacial Centre, Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Finland.
Hanna M OllilaBroad Institute, Cambridge, MA, USA; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Tianyi HuangLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
Russell P TracyDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Craig JohnsonDepartment of Biostatistics, University of Washington, Seattle, USA.
Stephen S RichDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.
Clary B ClishMetabolite Profiling Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jerome I RotterDepartment of Paediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Centre, Torrance, CA, USA.
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard University Medical School, Boston, MA, USA.
Tamar SoferDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Sleep Medicine, Harvard University Medical School, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Heming WangDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute, Cambridge, MA, USA; Division of Sleep Medicine, Harvard University Medical School, Boston, MA, USA.

Funding

CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Using polygenic risk scores and omics to study how suboptimal sleep accelerates cognitive aging in diverse populationsR01AG080598 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Tamar Sofer · 2023 to 2026
$3.6M
Leveraging omics data to understand sleep health and its consequences among diverse Hispanics/LatinosR01HL161012 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Tamar Sofer · 2022 to 2026
$3.2M
Dissecting heterogeneity of excessive daytime sleepiness and impact on cardiovascular diseasesR01HL153814 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, HEMING · 2021 to 2025
$2.0M
Pathway-level transcriptional causal mechanism of sleep disordered breathingR21HL165324 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, HEMING · 2023 to 2024
$264k
NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL153814NHLBI NIH HHS R01 HL161012NHLBI NIH HHS R21 HL165324NIA NIH HHS R01 AG080598
6 · The paper itself

Abstract

backgroundExcessive daytime sleepiness (EDS) is a complex sleep problem that affects approximately 33% of the United States population. Although EDS usually occurs in conjunction with insufficient sleep and other sleep and circadian disorders, recent studies have shown unique genetic markers and metabolic pathways underlying EDS. Here, we aimed to further elucidate the biological profile of EDS using large-scale single- and pathway-level metabolomics analyses.

methodsMetabolomics data were available for 877 metabolites in 6071 individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). EDS was assessed using the Epworth Sleepiness Scale (ESS) questionnaire. We performed linear regression for each metabolite on the continuous ESS score, adjusting for demographic, lifestyle, and physiological confounders, and in sex specific groups. Subsequently, gaussian graphical modelling was performed coupled with pathway and enrichment analyses to generate a holistic interactive network of the metabolomic profile of EDS associations.

findingsWe identified seven metabolites belonging to steroids, sphingomyelin, and long-chain fatty acids sub-pathways in the primary model associated with EDS, and an additional three metabolites in the male-specific analysis.

interpretationOur findings indicate that an EDS metabolomic profile is characterised by endogenous and dietary metabolites within the steroid hormone biosynthesis pathway, with some pathways that differ by sex. These pathways may be useful for understanding the causes or consequences of EDS and related sleep disorders.

fundingDetails regarding funding supporting this work and all studies involved are provided in the acknowledgements section.

Indexed as

DietDisorders of Excessive SomnolenceMetabolomeSteroidsAdultAgedBiomarkersFemaleHumansMaleMetabolic Networks and PathwaysMetabolomicsMiddle AgedBiomarkersSteroidsExcessive daytime sleepinessMendelian randomisationMetabolomicsNetwork analysisNutritionSex steroid hormones

Identifiers

PMID40835488
PMCPMC12789706

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.