ArticleBiochemistry2025
Raman Spectroscopy and Imaging Reveal the Effect of β-Carotene Supplementation on Brain Cancer Cells.
Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Super-Multiplexed Label-Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- All-trans-retinal as a modulator of metabolic and mitochondrial signatures in non-tumorigenic and malignant breast cells: a Raman-based approach.Mikrochimica acta · 2025Article
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Authors and funding
4 authors.
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Abstract
Dietary β-carotene is the most common carotenoid in the world. Naturally occurs in vegetables and fruits (e.g., carrots, tomatoes). Recently, β-carotene has been studied for its effects on the human body; however, the effect of this carotenoid on brain tumor metabolism at the cellular level is still unknown. Here, we consider whether β-carotene influences brain tumor cell metabolism and, if so, whether this effect stimulates or inhibits tumor growth. To find out the effect of β-carotene on brain cells (normal human astrocytes, astrocytoma, and glioblastoma), we applied Raman spectroscopy and imaging. We focused our analysis on biological changes in particular cell organelles such as the nucleus, mitochondria, lipid droplets/endoplasmic reticulum, and cytoplasm. Our Raman results demonstrated that cancer cell metabolism is altered following β-carotene supplementation, as reflected in changes to Raman bands associated with cytochrome
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