ArticleAnnals of medicine2025
Association between C-reactive protein-albumin-lymphocyte (CALLY) index with intravenous immunoglobulin non-response in Kawasaki disease.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Clinical Prognostic Impact of CALLY in Heart Failure Patients With Different Ejection Fractions: A Retrospective Study.Reviews in cardiovascular medicine · 2026Article
- The cally index as an indicator of inflammatory burden across clinical phases of familial mediterranean fever.Clinical rheumatology · 2026Article
- The association between CALLY index and obesity in adolescents: a comparative analysis with traditional inflammatory markers.Eating and weight disorders : EWD · 2026Article
- Development and internal validation of a monocyte-to-albumin ratio-based risk assessment model for coronary artery lesions in Kawasaki disease.Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe CRP-albumin-lymphocyte (CALLY) index has been demonstrated to be a predictive tool for tumors. However, studies on its role and clinical significance in predicting intravenous immunoglobulin (IVIG) non-response in patients with Kawasaki disease (KD) remains limited.
methodsA cohort of 975 patients with KD was recruited from four medical centers to examine their clinical and laboratory characteristics. Logistic regression analysis was employed to evaluate the association between CALLY and IVIG non-response in KD patients. Restricted cubic spline (RCS) regression models were utilized to explore potential nonlinear relationships. Subgroup analyses were also conducted. The predictive capability of CALLY was compared to that of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the ratio of C-reactive protein to albumin (CAR).
resultsRegardless of adjustments for confounding variables, CALLY, whether considered as a continuous or categorical variable, demonstrated a negative association with IVIG non-response. The relationship between the natural logarithm-transformed CALLY and IVIG non-response exhibited a non-linear trend, with a threshold identified at -0.752. Below this threshold, a negative association was observed between ln CALLY and IVIG non-response; however, no significant association was detected above the threshold. Subgroup analyses revealed no significant interactions between CALLY and IVIG non-response (all
conclusionThe CALLY parameter demonstrated a negative and nonlinear correlation with the risk of IVIG non-response, outperforming traditional inflammatory markers in predicting IVIG non-response.
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