ArticleScientific reports2025
Impact of PM2.5 exposure on acute toxicities and survival outcomes in radiotherapy for cervical cancer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Radiologic exposomics: imaging the environmental imprint on cancer for precision oncology.La Radiologia medica · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
Particulate matter with a diameter less than 2.5 micrometers (PM2.5) remains a persistent environmental challenge in upper Northern Thailand. This study aimed to investigate whether exposure to PM2.5 during radiotherapy influences treatment-related acute toxicities and survival outcomes in cervical cancer patients. We retrospectively reviewed data from 411 cervical cancer patients diagnosed between 2013 and 2018 at Maharaj Nakorn Chiang Mai Hospital. Clinical data were obtained from medical records and the Chiang Mai Cancer Registry. Mean daily PM2.5 exposure during radiotherapy period was estimated using the data from the Copernicus Atmosphere Monitoring Service. Acute toxicity parameters, including gastrointestinal (GI), genitourinary (GU), and hematologic (anemia, leukopenia, and thrombocytopenia) toxicities, were analyzed using chi-square tests and logistic regression models. Survival outcomes-including locoregional control, distant metastasis, disease-free survival, and overall survival-were estimated using Kaplan-Meier curves and Cox proportional hazards models. Most patients (90%) had locally advanced disease, and nearly 80% received brachytherapy and chemotherapy. Patients exposed to mean daily PM2.5 levels above 25 [Formula: see text] had a significantly increased risk of developing GU toxicity (adjusted odds ratio 2.4; 95% confidence interval 1.3-4.2; p < 0.01). In contrast, PM2.5 exposure was not significantly associated with GI or hematologic toxicities, nor with differences in locoregional control, distant metastasis, disease-free survival, or overall survival. These findings suggest that daily PM2.5 exposure more than 25 [Formula: see text] is associated with a higher incidence of acute GU toxicity.
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