SynthesisScientific reports2025
A systematic review and dose response meta analysis of Omega 3 supplementation on cognitive function.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Article
- Food-Derived Omega-3 Fatty Acids and Cognitive Aging: Integrating Nutritional Neuroscience and Geroscience.Nutrients · 2026Review
- The Gut-Brain-Skin Axis: Systemic Effects of Functional Ingredients in Healthy Skin Aging.International journal of molecular sciences · 2026Review
- Omega-3 Fatty Acids and Alzheimer's Disease: Toward a New Understanding of Neuroprotective Mechanisms and Intervention Strategies.Marine drugs · 2026Review
- The association between omega-3 supplementation and cognitive decline in older adults.The journal of prevention of Alzheimer's disease · 2026Article
- Optimizing Omega-3 Polyunsaturated Fatty Acids for Healthy Ageing: Human Intake Evidence and Dairy Cow Dietary Interventions for Milk Enrichment.Foods (Basel, Switzerland) · 2026Review
- Adherence to the Mediterranean diet, inflammatory biomarkers and cognitive status in older Italian adults.Frontiers in nutrition · 2026Article
- Targeting the cardio-neuro axis through nutrition: inflammatory mechanisms linking cardiovascular and neurodegenerative diseases.Frontiers in nutrition · 2026Article
- Eicosapentaenoic acid in emotional well-being and brain aging: evidence boundaries, clinical heterogeneity, and a peripheral-to-central resolution-biology framework.Frontiers in nutrition · 2026Review
- Nutrients and bioactive compounds as modifiers of neurodegenerative trajectories: molecular mechanisms, translational barriers, and precision nutrition.Frontiers in nutrition · 2026Review
- Nourishing the Brain or the Mood? Dietary Omega-3s for Psychological, but Not Cognitive Health.Nutrients · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dose-dependent effects of omega-3 supplementation on cognitive function remain unclear. This study aimed to evaluate the relationship between omega-3 dosage and cognitive outcomes in adults. A systematic search was conducted in PubMed, Scopus, and ISI Web of Science up to December 2024. Only randomized controlled trials (RCTs) were included. For each trial, we estimated the change in cognitive function per 2000 mg/day increment in omega-3 supplementation. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Dose-dependent effects were assessed through a dose-response meta-analysis of mean differences. The certainty of the evidence was evaluated using the GRADE approach. In total, 58 studies met the inclusion criteria. Each 2000 mg/d omega-3 supplementation showed a significant improvement in attention (SMD: 0.98; 95%CI: 0.41,1.54; GRADE = low), perceptual speed (SMD: 0.50; 95%CI: 0.05,0.95; GRADE = moderate) language (SMD: 0.98; 95%CI: 0.41,1.54; GRADE = low), primary memory (SMD: 0.87; 95%CI: 0.17,1.56; GRADE = moderate), visuospatial functions (SMD: 0.86; 95%CI: 0.46,1.27; GRADE = moderate), global cognitive abilities (SMD: 1.08; 95%CI: 0.73,1.44; GRADE = low). Levels of episodic memory decreased with the increase in omega-3 dose and then appeared to increase with an upward curve (P for non-linearity = 0.01, P for dose-response = 0.005). Levels of global cognitive abilities increased with the increase in omega-3 dosage, and then appeared to decreased with a downward curve (P for non-linearity = 0.008, P for dose-response = 0.002). The existing evidence suggests that omega-3 supplementation may lead to a modest improvement in cognitive function among adults. However, well-designed randomized trials with long-term follow-up are necessary to confirm and strengthen these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.