ArticleEuropean radiology2026
Node-RADS for preoperative locoregional nodal staging of endometrial cancer: reproducibility and accuracy assessment using CT and MRI.
Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Preoperative Prediction of Lymphovascular Space Invasion in Endometrial Cancer Using Diffusion MRI-Derived Vessel Density.Korean journal of radiology · 2026Article
- Assessment of inter-reader agreement and diagnostic performance of Node-RADS in colon cancer.Insights into imaging · 2026Article
- Prognostic and Diagnostic Value of Node-RADS for Non-Small Cell Lung Cancer Following Neoadjuvant Therapy: A Multicenter Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Comparing multi-b-value diffusion models and ROI delineation strategies for prediction of p53 abnormality and microsatellite instability in endometrial cancer.BMC medical imaging · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the reproducibility and diagnostic accuracy of the Node Reporting and Data System 1.0 (Node-RADS) for detecting pelvic nodal metastases by endometrial cancer (EC) using CT and MRI, among readers with different levels of expertise. MATERIALS AND
methodsThis IRB-approved, single-center retrospective study included 128 patients with EC who underwent preoperative MRI at our Institution (Jan 2020-Dec 2023). Six readers with different levels of expertise in pelvic MRI (2 dedicated pelvic radiologists, 2 residents in their fourth year of training, and 2 residents in their second year of training) independently evaluated preoperative CTs and MRIs and assigned Node-RADS scores. Inter-observer agreement and inter-method agreement were calculated. Node-RADS was compared with post-surgical pathology data.
resultsAt surgery, pelvic nodal metastases were detected in 12.5% of the patients. Interobserver agreement in nodal status assessment using Node-RADS varied from κ = 0.783 to κ = 0.426 using MRI, and from κ = 0.936 to κ = 0.295 using CT, with worse results among less experienced readers. MRI and CT were concordant in the N definition in 94-98% of the cases. Using MRI, the most experienced readers showed 63% sensitivity and 100% specificity in the detection of nodal metastases, compared to 44% sensitivity and 96% specificity for poorly experienced readers. Using CT, the most experienced readers showed 50% sensitivity and 100% specificity; the less experienced readers showed 43% sensitivity and 94% specificity.
conclusionsNode-RADS is a reproducible and accurate tool for locoregional nodal staging of EC, but only for readers with specific experience in pelvic imaging. MRI outperforms CT in nodal assessment. KEY POINTS: Question Preoperative assessment of nodal metastases by EC is difficult, but it may help in tailoring the best surgical approach for each patient. Findings Node-RADS is a reliable tool for assessing the presence of pelvic nodal metastases by EC, both on CT and MRI, among experienced readers. Clinical relevance The use of Node-RADS among experienced readers enables detection of nodal metastases with good sensitivity and excellent specificity; MRI should be preferred over CT due to its higher sensitivity.
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