Evidence map›Paper›PMID 40836110›Full record

Observational studyInternational journal of obesity (2005)2025

The long-term effect of metabolic bariatric surgery on innate immune cell phenotype and function.

Julia van Tuijl, Debby Vreeken, Wieteke Broeders, Benjamin Cossins, Liesbeth van Emst, Florine Seidel, Rinke Stienstra, Yang Li, Leo A B Joosten, Mihai G Netea and 5 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Julia van TuijlDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Debby VreekenDepartment of Medical Imaging, Anatomy, Radboud Alzheimer Center, Donders Institute for Brain Cognition and Behaviour, Center of Medical Neuroscience, Nijmegen, the Netherlands.
Wieteke BroedersDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Benjamin CossinsDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0002-0935-2198
Liesbeth van EmstDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Florine SeidelDepartment of Medical Imaging, Anatomy, Radboud Alzheimer Center, Donders Institute for Brain Cognition and Behaviour, Center of Medical Neuroscience, Nijmegen, the Netherlands.
Rinke StienstraDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Yang LiDepartment of Computational Biology for Individualized Medicine, Centre for Individualized Infection Medicine & TWINCORE, Joint ventures between the Helmholtz-Centre for Infection Research and the Hannover Medical School, Hannover, Germany.
Leo A B JoostenDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0001-6166-9830
Mihai G NeteaDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0003-2421-6052
Eric J HazebroekDepartment of Bariatric Surgery, Vitalys, Rijnstate Hospital, Arnhem, the Netherlands.
Robert KleemannDepartment for Metabolic Health Research, The Netherlands Organization for Applied Scientific Research TNO, Leiden, The Netherlands.
Amanda J KiliaanDepartment of Medical Imaging, Anatomy, Radboud Alzheimer Center, Donders Institute for Brain Cognition and Behaviour, Center of Medical Neuroscience, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0002-2158-6210
Siroon BekkeringDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0003-1149-466X
Niels P RiksenDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands. Niels.Riksen@radboudumc.nl.ORCID http://orcid.org/0000-0001-9197-8124

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesObesity is an important risk factor for atherosclerotic cardiovascular disease. This cardiovascular risk remains increased even after substantial weight loss by bariatric surgery. Innate immune cells are important regulators of atherogenesis and can adopt a long-term hyperinflammatory phenotype via epigenetic reprogramming, called "trained immunity". In this translational observational case-cohort study, we investigated the persistence of innate immune cell hyperresponsiveness following bariatric surgery, and explored the potential contribution of adipose tissue in ex vivo models. SUBJECTS/

methodsIn a cohort of 27 patients with obesity blood was drawn before and six months after bariatric surgery, and compared to 20 healthy subjects with normal body weight. We assessed monocytes using flow cytometry, functional assays, and RNA sequencing and chromatin immunoprecipitation. In an accompanying series of in vitro studies, healthy donor monocytes were exposed for 24 h to adipose tissue obtained from patients with obesity during bariatric surgery. Cytokine production capacity was assessed after one week.

resultsIn our case-cohort study, although leukocyte numbers and systemic inflammatory markers such as hs-CRP decreased after bariatric surgery to the level of normal weight control subjects, the hyperresponsive pro-inflammatory monocyte phenotype was only partially reverted six months after bariatric surgery, which aligned with the RNA expression profiles. Exposure of monocytes to adipose tissue obtained from patients with obesity induces a persistent augmented cytokine production capacity.

conclusionsAlthough in patients with obesity, six months after bariatric surgery systemic inflammatory markers and leukocyte numbers are decreased to the levels observed in healthy lean subjects, there is still a residual functional and transcriptional hyper-inflammatory monocyte phenotype. This might be caused, at least in part, by the capacity of adipose tissue to induce long-term pro-inflammatory effects in monocytes. These finding help to understand the long-term effects of obesity and bariatric surgery on cardiovascular health.

Indexed as

Bariatric SurgeryImmunity, InnateMonocytesObesityObesity, MorbidAdipose TissueAdultCase-Control StudiesCohort StudiesFemaleHumansMaleMiddle AgedPhenotype

Identifiers

PMID40836110

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.