ArticleAnnals of medicine2025
Exosomal miR-216a-5p targeting TLR-4 alleviates liver ischemia-reperfusion injury by regulating M2 macrophage polarization and neutrophil inflammation.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regulatory Mechanisms Within Multicellular Signaling Networks in Liver Ischemia-Reperfusion Injury: A Systematic Review Focusing on Cell-Type-Specific Interactions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Pooled it
- Rs1347093 polymorphism contributes to radiation pneumonitis in lung cancer patients through regulating miR-216a-5p expression.Functional & integrative genomics · 2026Article
- Advances in understanding exosome-mediated regulation of macrophage function.Frontiers in immunology · 2026Review
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophages and neutrophil play a key role in the initiation and recovery of liver ischemia reperfusion injury (IRI) through transitions in the phenotype and induces inflammation, However, the mechanisms governing these damages have yet to be fully elucidated. Exosomes have emerged as an important mediator of cellular crosstalk in various physiological and pathological processes. This study explored the role of exosomal miRNA in macrophage polarization and liver IRI. Through high-throughput sequencing of small RNAs in exosomes, we identified the negative regulator miR-216a-5p in liver IRI. Mechanistically, miR-216a-5p skewed M2 macrophage polarization and inhibited neutrophil infiltration by targeting TLR4. In conclusion, we demonstrated that exosome-derived miR-216a-5p favors an anti-inflammatory environment by promoting the M2 polarization of macrophages and inhibiting the neutrophil inflammatory response by targeting the TLR4/NF-κB and PI3K/AKT signaling pathways, revealing the endogenous protective mechanism in liver IRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.