Observational studyEuropean journal of medical research2025
Serum LACC1 level is a predictor of response to upadacitinib treatment in patients with rheumatoid arthritis: a prospective observational cohort study.
Observational study in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The research progress of LACC1.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveThis study investigates the predictive capacity of LACC1 regarding the response to upadacitinib (UPA) in individuals with rheumatoid arthritis (RA).
methodsThe study involved sixty adult patients with active RA who either did not respond well to or could not tolerate methotrexate. The regimen involved UPA monotherapy at 15 mg/day, while maintaining a fixed dose of glucocorticoids was acceptable. Follow-up was planned for 24 weeks. Treatment response was assessed using Clinical Disease Activity Index, Simplified Disease Activity Index, tender joint count (TJC), swollen joint count, and Health Assessment Questionnaire. Moreover, parameters associated with treatment response to UPA were measured.
resultsSerum LACC1 levels may be protective in predicting response to UPA therapy. Age, prolonged disease duration, increased use of csDMARDs, low neutrophil counts, and higher inflammatory markers were strongly associated with non-good response. Prolonged disease duration, increased TJC/68, low neutrophil count, and high GM-CSF levels were all independent unfavorable predictors of good response to UPA treatment, while higher serum LACC1 levels were more helpful in predicting good response. Patients with an extended disease course, high TJC/68, and significantly increased inflammatory cytokines should be advised of the potential for poor early outcomes.
conclusionHigher serum LACC1 levels are associated with better efficacy of UPA, with implications for optimizing clinical individualized dosing strategies.
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