Trial reportJournal of orthopaedic surgery and research2025
Reduced opioids after total joint replacement surgery (REPAIRS): a pilot randomized controlled trial.
Trial report in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Correction: Reduced opioids after total joint replacement surgery (REPAIRS): a pilot randomized controlled trial.Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOpioid analgesics are commonly used for controlling pain after total knee or hip replacement. However, it is unclear how much opioid should be prescribed at discharge after total hip and knee replacement surgery to optimize pain management but minimise adverse events. To determine the acceptability and feasibility of a trial comparing a reduced and standard opioid regimen following discharge from total knee or hip replacement.
methodsThis pilot randomized controlled trial recruited participants from the pre-admission clinic of a metropolitan hospital in Sydney. All participants received a non-opioid regimen of naproxen 500 mg 12 hourly for 7 days, and paracetamol 1000 mg 6 hourly daily for 14 days. Participants were randomly allocated to the 'standard' group (oxycodone 5 mg taken as needed, maximum recommended frequency of 4 hourly, 20 tablets dispensed) or the 'reduced' group (received half the amount of oxycodone, taken half as frequently) at hospital discharge. Primary outcomes were screening to recruitment rate, percentage completing follow-ups, and acceptability of the trial procedures. Acceptability was measured quantitatively at weeks 1 and 2 post-discharge and qualitatively by interview at 6 weeks post-discharge. Adverse events were collected up to 6-weeks post-discharge.
resultsIn four months, we screened 254 people, of which 72 were eligible and 53 were recruited (recruitment rate = 21%). 93% participants completed all their follow up surveys. Participants scored the trial intervention between neutral and acceptable (3.6/5 for both groups and weeks). 39 interviews were conducted where both clinicians and patients reported strong support for the pilot trial design. Few adverse events occurred across both groups, the most common being constipation.
conclusionsThis pilot trial indicated that a full-scale trial would be feasible and acceptable. Such a trial could provide evidence of comparative effectiveness for the reduced opioid regimen in this population.
trial registrationThe trial was pre-registered in Australian New Zealand Clinical Trials Registry (ACTRN12623001070628).
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