ArticleInternational journal of retina and vitreous2025
Early photoreceptor assessment as a predictor for visual acuity gain after vitrectomy for macula-off retinal detachment.
Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Advanced Preoperative Imaging in Macula-Off Rhegmatogenous Retinal Detachment: Emerging Diagnostic and Prognostic Insights for Clinical Management.Diagnostics (Basel, Switzerland) · 2026Review
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundVisual recovery after macula-off rhegmatogenous retinal detachment (RRD) remains limited in many cases, largely due to photoreceptor damage. This study aimed to assess the predictive value of early outer retinal findings on optical coherence tomography (OCT) for visual acuity outcomes.
methodsA retrospective, longitudinal study was conducted on 106 eyes with macula-off RRD treated with vitrectomy and gas tamponade. The primary outcome was best-corrected visual acuity (BCVA) at six months postoperatively. Predictive variables included ellipsoid zone (EZ) and external limiting membrane (ELM) integrity, relative EZ reflectivity (rEZR) at one month, as well as age, time to surgery, macular status, baseline BCVA, and RRD extension. Associations were analyzed using linear regression models.
resultsOne-month ELM and EZ integrity were independent predictors of six-month BCVA after adjusting for rEZR and baseline LogMAR BCVA (ELM absence: ß=0.33; EZ absence: ß=0.20; both p < 0.04). rEZR increased significantly between one and six months (p < 0.05), stabilizing thereafter, and moderately correlated with BCVA (r=-0.6). Other variables were not significant in univariate analysis and were excluded from the multivariate model.
conclusionsAbsence of the ELM at one month indicates poor visual prognosis, corresponding to an estimated four-line visual loss. rEZR may serve as a sensitive marker of photoreceptor metabolic recovery. These findings support the development of imaging-based deep learning models for visual outcome prediction in macula-off RRD.
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