SynthesisClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Oral Anticoagulant Therapy in Patients with Atrial Fibrillation After Intracranial Hemorrhage: A Meta-Analysis of Randomized Controlled Trials.
Synthesis in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundThe management of atrial fibrillation (AF) in patients with a history of intracranial hemorrhage (ICH) presents a significant clinical challenge. Although oral anticoagulants (OACs), have been shown to effectively reduce thromboembolic events in AF patients, their use in survivors of ICH raises concerns regarding the risk of recurrent bleeding. In this study, we conduct a systematic review of randomized controlled trials (RCTs) to assess the safety and efficacy of OAC therapy in AF patients following ICH.MethodsWe searched PubMed/Embase for RCTs assessing OACs in AF patients with ICH history. Efficacy outcomes included ischemic stroke, major vascular events, stroke or vascular death, major embolic events, and all-cause mortality.ResultsA total of three RCTs with 623 participants were included. Compared to no anticoagulation or antiplatelet therapy alone, OAC did not significantly reduce the risk of ischemic stroke (HR = 0.27, 95% CI [0.02, 3.92],
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.