SynthesisInternational health2026
Risk factors and mortality rates for children co-infected with HIV and TB in Ethiopia: a systematic review and meta-analysis.
Synthesis in International health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Defective IL-17 production is associated with reduced IL-1β levels in response toFrontiers in immunology · 2026Article
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6 authors.
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Abstract
This systematic review and meta-analysis aimed to identify risk factors and mortality rates in HIV and TB co-infected children in Ethiopia. An electronic literature search was conducted using multiple databases, including PubMed, Medline, Web of Science, African Journal Online, Google Scholar and university research repositories for gray literature. Weighted inverse variance random-effects meta-regression was employed to calculate pooled mortality rates, utilizing Stata/SE-17 for analysis. The meta-analysis included six eligible studies, encompassing a total of 2025 co-infected children. Among these, 238 deaths were reported over 1670.6 person-years. This made the crude mortality rate 11.74% (95% CI 11.49 to 16.12%) with an incidence of 1.5 deaths (95% CI 1.17 to 1.89) per 100 person-years. Factors including WHO stages III and IV (4.34, 95% CI 2.25 to 8.36), poor antiretroviral therapy (ART) adherence (3.11, 95% CI 2.04 to 4.15), missed isoniazid preventive therapy (IPT) (3.07, 95% CI 1.52 to 6.23) and low hemoglobin levels of ≤10 mg/dl (2.84, 95% CI 2.02 to 3.99) were predictors compared with their counterparts.This review reveals an unacceptably high pooled incidence of mortality among HIV and TB co-infected children in Ethiopia. Therefore, implementing systematic screenings for IPT, enhancing ART adherence counseling and addressing anemia through early treatment are critical for preventing premature deaths. Protocol registration in Prospero = CRD42024502038.
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