Evidence mapPaperPMID 40836909Full record

ReviewJournal of comparative effectiveness research2025

Transportability of nonlocal real-world evidence and its relevance to health technology assessment: a primer.

Alind Gupta, Stephen Duffield, Cal Shephard, Eon Ting, Sanjay Popat, Winson Y Cheung, Paul Arora

Abstract readReview
In one paragraph

Review in Journal of comparative effectiveness research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alind GuptaDalla Lana School of Public Health (DLSPH), University of Toronto, Toronto, Canada.ORCID 0000-0003-1139-9769
Stephen DuffieldNational Institute for Health & Care Excellence (NICE), London, UK.
Cal ShephardAstraZeneca Canada, Mississauga, Canada.
Eon TingAstraZeneca Canada, Mississauga, Canada.
Sanjay PopatThe Royal Marsden, NHS Foundation Trust, London, UK.ORCID 0000-0003-2087-4963
Winson Y CheungInka Health, Toronto, Canada.ORCID 0000-0002-3679-4290
Paul AroraDalla Lana School of Public Health (DLSPH), University of Toronto, Toronto, Canada.ORCID 0000-0001-6617-3631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-world evidence (RWE) from outside Canada or the UK is sometimes included in submissions to health technology assessments by Canada's Drug Agency/L'Agence des médicaments du Canada (CDA-AMC) and National Institute for Health and Care Excellence when local data are lacking, particularly in rare diseases. However, differences in population demographics, healthcare systems and clinical practice patterns between different jurisdictions can pose challenges for contextualizing nonlocal data for health technology assessments. This primer outlines the challenges of using nonlocal RWE for decision-making, presents assumptions necessary for transportability of RWE, and describes quantitative methods to address these challenges. This primer is written for a broad audience, including industry stakeholders, researchers and clinicians, who are seeking accessible guidance on the use of nonlocal RWE and developments in the field of transportability.

Indexed as

Technology Assessment, BiomedicalCanadaDecision MakingHumansgeneralizabilityhealth technology assessmentreal-world evidencetransportability

Identifiers

PMID40836909
PMCPMC12465918

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.