Evidence map›Paper›PMID 40837229›Full record

ArticleiScience2025

Functional characterization of the Csm1-like protein TITAN 9 in

Zhijian Zhang, Franziska Böwer, Shinichiro Komaki, Aladár Pettkó-Szandtner, Anastasiia O Skuba, Eelco C Tromer, Zoltán Magyar, Maren Heese, Arp Schnittger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhijian ZhangDepartment of Developmental Biology, Institute for Plant Sciences and Microbiology, University of Hamburg, 22609 Hamburg, Germany.
Franziska BöwerDepartment of Developmental Biology, Institute for Plant Sciences and Microbiology, University of Hamburg, 22609 Hamburg, Germany.
Shinichiro KomakiGraduate School of Science and Technology, Nara Institute of Science and Technology, Nara 630-0192, Japan.
Aladár Pettkó-SzandtnerProteomics Research Group, Core Facility, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
Anastasiia O SkubaDepartment of Developmental Biology, Institute for Plant Sciences and Microbiology, University of Hamburg, 22609 Hamburg, Germany.
Eelco C TromerCell Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Faculty of Science and Engineering, University of Groningen, Groningen, the Netherlands.
Zoltán MagyarInstitute of Plant Biology, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
Maren HeeseDepartment of Developmental Biology, Institute for Plant Sciences and Microbiology, University of Hamburg, 22609 Hamburg, Germany.
Arp SchnittgerDepartment of Developmental Biology, Institute for Plant Sciences and Microbiology, University of Hamburg, 22609 Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kinetochores are essential for chromosome segregation in eukaryotes. An important component of kinetochores in opisthokonta is Csm1. However, its function appears to be diversified and, while Csm1 in budding yeast is a component of the monopolin complex mediating mono-orientation of sister kinetochores during meiosis I, the fission yeast homolog Pcs1 prevents merotelic spindle microtubule attachments during mitosis and meiosis II. Here, we have characterized TITAN9 (TTN9), a distantly related Csm1-like protein in the flowering plant Arabidopsis. TTN9 accumulates in mitotic and meiotic tissue and localizes to centromeres throughout the cell cycle. By analyzing proteome-wide TTN9 associated proteins, we identified a substantial subset of the Arabidopsis kinetochore proteome, including DSN1, mirroring known Csm1 interactions in yeast. While homozygous

Indexed as

plant bioinformaticsplant Biologyplant developmentplant evolutionplant geneticsplant physiologyplant systematics

Identifiers

PMID40837229
PMCPMC12362390

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.