ArticleWorld journal of diabetes2025
Gut dysbiosis, low-grade inflammation, and renal impairment severity in elderly diabetic nephropathy.
Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Mechanistic Insights intoMetabolites · 2026Article
- Unveiling the gut-kidney dialogue in diabetic kidney disease.World journal of diabetes · 2025Article
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5 authors.
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Abstract
backgroundThe specific mechanism of diabetic nephropathy (DN) has not been fully elucidated, and more and more evidence shows that the development of DN is related to intestinal flora imbalance and micro-inflammatory state process, and this mechanism urgently needs to be further clarified by relevant research.
aimTo investigate the correlation between intestinal microbiota dysbiosis, low-grade inflammatory status, renal function impairment, and disease severity in older patients with DN, in order to provide a basis for the prevention and therapeutic intervention of DN.
methodsWe enrolled 167 older patients with DN, diagnosed in the Department of Nephrology between June 2020 and June 2023. Eighty-five patients with type 2 diabetes mellitus (without DN) were enrolled to serve as the control group. A one-year follow-up observation was conducted. We compared the differences in gut microbiota composition, levels of inflammatory markers, and renal function indicators between the two groups, and the characteristics of gut microbiota and the changing patterns of inflammatory markers across different stages of disease progression.
resultsIn the DN group, the Chao, Ace, and Shannon indices were significantly lower, while the Simpson index was significantly higher than the control group. The relative abundances of
conclusionThe onset and progression of DN in older patients with diabetes are closely associated with gut microbiota composition. The more severe the dysbiosis, the lower the abundance of beneficial bacteria and the higher the abundance of harmful bacteria, leading to an increased risk of both DN occurrence and disease progression.
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