Evidence map›Paper›PMID 40837339›Full record

ArticleWorld journal of diabetes2025

Identification and mechanistic insights of ubiquitin-proteasome system and pyroptosis-related biomarkers in type 2 diabetes mellitus.

Xiao-Jing Yuan, Zi-Chen Zhang, Jie Li, Shan-Dong Ye, Wan Zhou

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Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xiao-Jing YuanDepartment of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China.
Zi-Chen ZhangDepartment of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China.
Jie LiDepartment of Endocrinology, Anhui Provincial Hospital, Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China.
Shan-Dong YeDepartment of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China.
Wan ZhouDepartment of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China. zwan@ustc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPyroptosis and ubiquitination have been identified as key processes influencing the pathogenesis of diabetes mellitus (DM).

aimTo investigate the genes associated with the ubiquitin-proteasome system (UPS) and pyroptosis in type 2 DM (T2DM), and elucidate their mechanisms of action in T2DM.

methodsThe datasets GSE76894, GSE41762, and GSE86469 were utilized in this study. UPS-related genes (UPSGs) and pyroptosis-related genes (PRGs) were obtained from existing literature. Differential expression analysis was performed to identify differentially expressed genes (DEGs). DEGs were intersected with UPSGs and PRGs to identify differentially expressed UPSGs and PRGs. Ubiquitin-pyroptosis-related biomarkers were determined using Spearman's correlation,

resultsA total of 581 DEGs were identified in GSE76894. Four genes [ATP binding cassette subfamily C member 8 (

conclusionThis study identified four ubiquitin-pyroptosis-related biomarkers (

Indexed as

BiomarkersIntercellular biocommunicationPyroptosisRegulatory networksType 2 diabetes mellitusUbiquitin-proteasome system

Identifiers

PMID40837339
PMCPMC12362490

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