ArticleWorld journal of diabetes2025
Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- A preliminary study on the combined assessment of 25-hydroxyvitamin D and thyroid function for predicting diabetic foot risk and amputation in type 2 diabetes.Frontiers in endocrinology · 2026Article
- Precision nutrition in diabetic foot ulcers: multimodal artificial intelligence for personalized metabolic management.Frontiers in nutrition · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic foot ulcers (DFUs) represent a common and serious complication of diabetes, characterized by impaired wound healing and an increased risk of infection. These infections severely impact patient health, necessitating extensive medical intervention, and increasing the risk of amputation. Vitamin D (VD) plays a critical role in immune regulation and tissue repair.
aimTo investigate the effects of VD supplementation on infection rates, wound healing, and immune function in patients with DFUs.
methodsA randomized controlled trial was conducted involving 120 patients with DFUs. Participants were randomly assigned to either a control group (
resultsThe incidence of infection was significantly lower in the VD supplementation group (25%) compared with the control group (45%) (
conclusionThe VD supplementation effectively reduced infection rate, promoted wound healing, and strengthened immune responses in patients with DFUs. These findings support the incorporation of VD as a safe and effective adjunctive therapy in the clinical management of DFUs.
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