ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
A Cross-Sectional Study of the Association Between Uric Acid-to-High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Carotid atherosclerosis (CAS) is a key diabetic complication needing predictive biomarkers. The serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR), linked to metabolic dysfunction, may serve this role. Therefore, this cross-sectional study examines UHR-CAS association in type 2 diabetes. Methods: This study included 615 type 2 diabetes patients, collecting demographic, biochemical, and carotid ultrasound data. Spearman correlation analyzed UHR's relationship with cardiovascular risk factors. Multivariate logistic regression combined with stratified regression modeling assessed UHR's independent link with CAS, while receiver operating characteristic (ROC) analysis evaluated its predictive value. Results: CAS patients showed elevated UHR and cardiovascular risk markers (age, body mass index [BMI], homeostatic model assessment of insulin resistance [HOMA-IR], systolic blood pressure, low-density lipoprotein cholesterol [LDL-c], triglycerides, smoking) compared to controls ( Conclusion: UHR is an independent CAS risk factor in type 2 diabetes, outperforming traditional biomarkers for cardiovascular risk assessment.
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