ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Assessment of the Association Between Cardiac Metabolic Markers and Carotid Atherosclerosis, and the Role of Insulin Resistance.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The mediating role of fasting plasma glucose and systolic blood pressure in the association between Chinese visceral adiposity index and carotid atherosclerosis: a cross-sectional study.Scientific reports · 2026Article
- Association Between Cardiometabolic Index and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
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Authors and funding
4 authors.
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Abstract
Background: Obesity is a growing global health concern. The cardiometabolic index (CMI), a novel marker of fat distribution, has been proposed as a potential risk indicator. This study investigates the association between CMI and carotid atherosclerosis (CAS), as assessed by carotid intima-media thickness (cIMT), and explores whether insulin resistance (IR) mediates this relationship. Methods: This cross-sectional study enrolled type 2 diabetes mellitus (T2DM) patients hospitalized at Cangzhou People's Hospital between September 2024 and March 2025. Logistic regression models, restricted cubic spline (RCS) analysis, and subgroup analysis were used to examine the CMI-CAS relationship. The predictive ability of CMI was assessed using receiver operating characteristic (ROC) curves, and its incremental value beyond traditional risk factors was evaluated by integrated discrimination improvement (IDI) and net reclassification improvement (NRI). Mediation analysis assessed the role of IR. Results: After adjustment, higher CMI was significantly associated with increased odds of CAS (OR = 1.48, 95% CI: 1.21-1.81, Conclusion: Elevated CMI is independently associated with higher risk of CAS in T2DM patients, and insulin resistance partially mediates this relationship. CMI may be a valuable marker for early vascular risk stratification in diabetic populations.
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