Evidence map›Paper›PMID 40837618›Full record

ArticleDrug and alcohol dependence reports2025

Impact of hepatitis C serostatus on health service utilization for opioid-related harms among individuals prescribed opioid agonist therapy: A longitudinal prospective cohort study.

Paige Guyatt, Glenda Babe, Anastasia Gayowsky, Tea Rosic, Myanca Rodrigues, Paxton Bach, Richard Perez, Claire de Oliveira, Jeffrey H Samet, Geneviève Kerkerian and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Paige GuyattMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON L8P 1H6, Canada.
Glenda BabeCenter for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Anastasia GayowskyICES McMaster, McMaster University, Hamilton, ON L8S 4L8, Canada.
Tea RosicDepartment of Health Research Methods Evidence and Impact, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Myanca RodriguesDepartment of Health Research Methods Evidence and Impact, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Paxton BachBritish Columbia Centre on Substance Use, Vancouver, BC V6Z 2A9, Canada.
Richard PerezICES McMaster, McMaster University, Hamilton, ON L8S 4L8, Canada.
Claire de OliveiraInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Jeffrey H SametDepartment of Medicine, Boston University Chobanian & Adevisian School of Medicine, Boston 02118, USA.
Geneviève KerkerianDivision of Social Medicine, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Jessica HannDepartment of Emergency Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Joanna C DionneDepartment of Health Research Methods Evidence and Impact, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Aijaz AhmedDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94304, USA.
Donghee KimDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94304, USA.
Seonaid NolanBritish Columbia Centre on Substance Use, Vancouver, BC V6Z 2A9, Canada.
Lehana ThabaneDepartment of Health Research Methods Evidence and Impact, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Zainab SamaanDepartment of Health Research Methods Evidence and Impact, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Brittany B DennisBritish Columbia Centre on Substance Use, Vancouver, BC V6Z 2A9, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Varied substance use outcomes have been reported among individuals with a hepatitis C viral (HCV) infection on opioid agonist treatment (OAT) for opioid use disorder. Accordingly, the current study sought to evaluate the association between HCV serostatus, among other factors, and opioid-related acute health service utilization (e.g., emergency department [ED] visits and hospitalizations) among individuals prescribed OAT. Methods: Multi-site prospective cohort study data were used to characterize demographic characteristics, substance use patterns, and physical health amongst individuals prescribed OAT. Logistic regression models were built to estimate the association between HCV-seropositivity and opioid-related ED visits and hospitalizations over a three-year follow up period. Results: Among 3430 participants, 10.6 % ( Conclusion: Among individuals prescribed OAT, those with seropositive HCV have increased incidence of ED visits and hospitalizations for opioid-related harms, an association which may be driven by injection use practices. These findings highlight the importance of screening for injection use practices and health symptoms, as well as the potential role for targeting resources (e.g., harm reduction supplies, education regarding transmission) within this vulnerable subgroup.

Indexed as

Hepatitis C virus (HCV)Opioid agonist therapy (OAT)Opioid related harms (ORH)Opioid use disorder (OUD)

Identifiers

PMID40837618
PMCPMC12361781

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.