Evidence map›Paper›PMID 40837791›Full record

ReviewWorld journal of psychiatry2025

Cell-free DNA in extracellular vesicles: A candidate biomarker of schizophrenia.

Yu-Long Bai, Shi-Fa Ma, Dong-Dong Qi, Chuang Guo, Peng Liu, Kuan-Jun He

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu-Long BaiCollege of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China.
Shi-Fa MaBasic and Clinical Laboratory of Mental Disorders, The Third People's Hospital of Hulunbuir, The Mental Health Center of Hulunbuir City, Hulunbuir 022150, Inner Mongolia Autonomous Region, China.
Dong-Dong QiBasic and Clinical Laboratory of Mental Disorders, The Third People's Hospital of Hulunbuir, The Mental Health Center of Hulunbuir City, Hulunbuir 022150, Inner Mongolia Autonomous Region, China.
Chuang GuoCollege of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China.
Peng LiuBasic and Clinical Laboratory of Mental Disorders, The Third People's Hospital of Hulunbuir, The Mental Health Center of Hulunbuir City, Hulunbuir 022150, Inner Mongolia Autonomous Region, China.
Kuan-Jun HeCollege of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China. hekuanjun@imun.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia (SCZ) is a severe mental disorder with significant impacts on individuals, families, and society. Previous research has indicated that SCZ patients will commonly face substantial impairments in mitochondrial function and oxidative phosphorylation in the brain. Cell-free DNA (cf-DNA), serving as a direct biomarker of apoptosis, offers a valuable vantage point to understand the complex cellular mechanisms underlying SCZ. This review is to explore the role of cf-DNA in the etiology and progression of SCZ and evaluate the potential of cf-DNA within extracellular vesicles (EVs) as a diagnostic biomarker. A review approach was employed to gather and analyze relevant literature on the role of cf-DNA in SCZ, especially focusing on the potential of cf-DNA within EVs as a diagnostic biomarker. This review found that cf-DNA within EVs holds the potential to improve diagnostic methods. It can offer more accurate and sensitive means for detecting SCZ. Moreover, it has the ability to optimize disease management strategies by providing information about the disease state. Also, it can promote the development of pharmacological treatments for SCZ. Integrating cf-DNA analysis into clinical practice can help clinicians utilize cf-DNA levels and its unique characteristics for early and accurate diagnosis. The analysis of cf-DNA, particularly cf-DNA within EVs, has significant potential in the context of SCZ. It can transform our understanding of the disorder, improve diagnostic approaches, optimize disease management, and foster the development of pharmacological treatments.

Indexed as

Cell-free DNAExtracellular vesiclesInflammationMitochondrial damageSchizophrenia

Identifiers

PMID40837791
PMCPMC12362620

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.