Evidence map›Paper›PMID 40838262›Full record

ArticleJournal of nutritional science2025

A healthful plant-based diet is associated with higher health-related quality of life among older adults independent of circulating CRP: a cross-sectional analysis from the Lifelines Cohort Study.

Kerstin Schorr, Marian Beekman, Venetka Agayn, Jeanne H M de Vries, Lisette C P G M de Groot, P Eline Slagboom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nutritional science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kerstin SchorrSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.ORCID https://orcid.org/0000-0002-5633-3002
Marian BeekmanSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
Venetka AgaynInnoso BV, Ruychrocklaan 68, 2597 EP The Hague, The Netherlands.
Jeanne H M de VriesDivision of Human Nutrition and Health, Wageningen University, P.O. Box 176700 AA Wageningen, The Netherlands.
Lisette C P G M de GrootDivision of Human Nutrition and Health, Wageningen University, P.O. Box 176700 AA Wageningen, The Netherlands.
P Eline SlagboomSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-based diets (PBD) have been found to be environmentally sustainable and beneficial for health. Observational research showed that higher plant-based diet quality improves health-related quality of life (HRQoL) in adult women, however this is unclear for older adults. This association may be due to anti-inflammatory properties of PBD. Older adults, prone to chronic inflammation, may therefore profit from PBD. We investigated the relation between PBD and HRQoL in older adults of both sexes and tested whether the effects are associated with circulating high-sensitivity C-reactive protein (hsCRP) levels. We used data of the population-based Lifelines Cohort Study (n = 6,635, mean age = 65.2 years) and a subsample in which hsCRP was measured (n = 2,251, mean age = 65.2 years). We applied a plant-based diet index measuring adherence to a healthful (hPDI) and an unhealthful (uPDI) plant-based diet based on food frequency questionnaires. The RAND-36 questionnaire was applied as measure of HRQoL, from which we derived physical and mental HRQoL. Older adults with the highest adherence to a hPDI had respectively 15% and 12% greater odds for high physical quality of life and mental quality of life. Meanwhile, higher adherence to uPDI was associated with respectively 16% and 13% lower odds for high physical and mental quality of life. An additive but no interactive effect of hsCRP on the association between PBD and HRQoL has been observed. Adherence to a healthful plant-based diet and circulating levels of inflammation are independently associated with physical and mental HRQoL. Mechanisms other than inflammation through which PBD could influence HRQoL may be explored in further research.

Indexed as

C-Reactive ProteinDiet, HealthyDiet, VegetarianQuality of LifeAgedCohort StudiesCross-Sectional StudiesDiet, Plant-BasedFemaleHumansInflammationMaleMiddle AgedSurveys and QuestionnairesC-Reactive ProteinDietary patternFFQ, food frequency questionnairehPDI, healthful plant-based diet indexhsCRP, high-sensitivity C-reactive proteinInflammationMCS, mental component scoreOlder adultsPCS, physical component scorePDI, Plant-based diet indexPlant-based dietSubjective well-beinguPDI, unhealthful plant-based diet index

Identifiers

PMID40838262
PMCPMC12361675

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.