Evidence mapPaperPMID 40838467Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

One-Step Coordinated Multi-Kinetic 4D Printing of Human Vascularized Cardiac Tissues with Selective Fast-Shrinking Capillaries.

Ester Sapir Baruch, Roni Cohen, Eric Silberman, Michael Namestnikov, Itai Cabilly, Assaf Shapira, Tal Dvir

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. A practical toolbox for modelling fibrosis in vitro.Nature biomedical engineering · 2026
    Review
  2. Review
  3. Prospects of Four-Dimensional Printing of Polymers for Biomedical Engineering.Polymer science & technology (Washington, D.C.) · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ester Sapir BaruchThe Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Roni CohenThe Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Eric SilbermanThe Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Michael NamestnikovThe Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Itai CabillyThe Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Assaf ShapiraThe Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Tal DvirThe Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.ORCID https://orcid.org/0000-0002-3153-9928

Funding

ERC Consolidator Grant 101001242Israeli Science Foundation 972/21Israeli Science Foundation- The Breakthrough Research Grants 1418/24NSF-BSF 220733Slezak Foundation
6 · The paper itself

Abstract

The field of 3D bioprinting has made substantial progress in recent years, enabling the fabrication of vascular networks within engineered tissues to support the efficient transfer of oxygen and nutrients. However, a critical limitation remains: the restricted resolution of cell-laden bioink hydrogels, which impedes the precise formation of microscale structures such as capillaries. In this study, a novel, sequential, one-step bioprinting approach is introduced that enables the deposition of multiple cell-laden bioinks, facilitating the fabrication of functional, complex cardiac tissues with hierarchical microvasculature. Remarkably, this strategy enables pre-designed blood vessels to undergo selective shrinkage to capillary-scale dimensions within the parenchymal tissue under physiological conditions. Engineered cardiac tissues with perfusable, endothelialized vascular networks exhibit robust contractile function, and in vivo implantation demonstrate successful anastomosis of the vasculature with the host. This bioprinting strategy represents a significant advancement in the engineering of physiologically relevant tissue architectures, paving the way for the development of functional organotypic constructs for regenerative medicine and transplantation.

Indexed as

BioprintingCapillariesHeartMyocardiumPrinting, Three-DimensionalTissue EngineeringAnimalsHumansHuman Umbilical Vein Endothelial CellsHydrogelsKineticsMiceNeovascularization, PhysiologicTissue ScaffoldsHydrogels4D printingbiomaterialsengineered cardiac tissuestem cellsvascularization

Identifiers

PMID40838467
PMCPMC12801373

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.