SynthesisFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Towards Microbiota-Targeted Interventions in Acute Pancreatitis: Evidence From Meta-Analysis and Mendelian Randomization.
Synthesis in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Towards Microbiota-Targeted Interventions in Acute Pancreatitis: Evidence From Meta-Analysis and Mendelian Randomization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have established a causal relationship between gut microbiota and acute pancreatitis (AP) using Mendelian randomization (MR) methods, with a predominant focus on European populations. This study aimed to systematically evaluate this association through meta-analysis and bidirectional MR in East Asian populations. The meta-analysis integrated data from 10 studies, revealing that gut dysbiosis significantly increased AP risk, with the "other functional microbiota" showing the most substantial effect. The MR analysis, utilizing large-scale genome-wide association study data, identified potential causal relationships between specific gut microbiota taxa and AP in both European and East Asian populations. Notably, specific taxa, such as Olsenella and Clostridium leptum, were associated with an increased AP risk, while Odoribacter exhibited protective effects. These findings support the potential for microbiota-targeted interventions in AP and emphasize the consistency of the association between gut dysbiosis and AP risk across diverse populations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.