ArticleHuman brain mapping2025
Random Walk-Based Node Feature Learning for Major Depressive Disorder Identification Through Multi-Site rs-fMRI Data.
Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- MMDD: A Multimodal Multitask Dynamic Disentanglement Framework for Robust Major Depressive Disorder Diagnosis Across Neuroimaging Sites.Diagnostics (Basel, Switzerland) · 2025Article
- Random Walk-Based Node Feature Learning for Major Depressive Disorder Identification Through Multi-Site rs-fMRI Data.Human brain mapping · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
Major depressive disorder (MDD) is a globally prevalent psychiatric disorder that significantly impairs quality of life and increases suicide risk. Accurate identification of MDD is critical for clinically assisted diagnosis. Although substantial progress has been made in MDD identification, extracting region of interest (ROI) features from functional brain networks remains underexplored. Furthermore, most studies rely on small-scale resting-state functional magnetic resonance imaging (rs-fMRI) datasets, which limits the generalizability of their findings to large-scale brain networks. To address these issues, we propose a novel graph embedding-based feature selection classification framework (GEF-FSC) to identify MDD through multi-site rs-fMRI data. The framework employs the node2vec algorithm to learn local and global functional connectivity (FC) features of ROIs via flexible random walks, capturing structural information in functional brain networks. Random Forest is then applied for feature selection on the learned embedding features, followed by classification using an ensemble classifier. This approach captures complex, higher-order structural information between ROIs and retains important features, enhancing classification accuracy by minimizing redundancy in high-dimensional FC features. Evaluated on the REST-meta-MDD dataset, our framework achieved 81.65% accuracy under the Dosenbach template and 75.30% under the AAL atlas. Comparative experiments with eight benchmark methods and six state-of-the-art classifiers demonstrated superior accuracy, sensitivity, specificity, and F1-score. Interpretability analysis highlighted key brain regions and networks consistent with previous findings. The GEF-FSC framework effectively classifies MDD and identifies key brain regions and networks associated with the disorder, emphasizing the importance of higher-order structural information in improving diagnostic accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.