Evidence map›Paper›PMID 40839232›Full record

SynthesisInternational journal of clinical oncology2025

A systematic review and meta-analysis of x-ray therapy versus proton beam therapy for pediatric central nervous system germ cell tumors: TRP-Germinoma 2025.

Sho Hosaka, Masashi Mizumoto, Hiroko Fukushima, Takashi Iizumi, Takashi Saito, Masako Inaba, Ryoko Suzuki, Yinuo Li, Kei Nakai, Shosei Shimizu and 4 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sho HosakaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, 305-8576, Japan.
Masashi MizumotoDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan. mizumoto@pmrc.tsukuba.ac.jp.
Hiroko FukushimaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, 305-8576, Japan.
Takashi IizumiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Takashi SaitoDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Masako InabaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, 305-8576, Japan.
Ryoko SuzukiDepartment of Child Health, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Yinuo LiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Kei NakaiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Shosei ShimizuDepartment of Pediatric Radiation Therapy Center/Pediatric Proton Beam Therapy Center, Hebei Yizhou Cancer Hospital, Zhuozhou City, 072750, China.
Yoshiko OshiroDepartment of Radiation Oncology, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki, 305-8558, Japan.
Kazushi MaruoDepartment of Biostatistics, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.
Hidetoshi TakadaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, 305-8576, Japan.
Hideyuki SakuraiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCentral nervous system germ cell tumors (CNS-GCTs) are rare pediatric tumors, categorized into germinomas and non-germinomatous germ cell tumors (NGGCTs). Proton-beam therapy (PBT) has been introduced as an alternative to X-ray therapy (XRT) for minimizing radiation exposure to normal brain tissue, but evidence comparing these treatment modalities is limited.

methodsA systematic review and meta-analysis following PRISMA guidelines was conducted using PubMed for studies published between 1990 and 2022. Studies reporting overall survival (OS) and progression-free survival (PFS) for CNS-GCTs treated with PBT or XRT were included. Random-effects meta-analyses compared 3- and 5-year OS and PFS between treatment modalities.

resultsForty-one studies were selected, with 36 on XRT and five on PBT. In germinoma patients, no significant differences were found between XRT and PBT for 3-year OS (95.3% vs 97.8%, p = 0.3158), 5-year OS (94.8% vs 97.8%, p = 0.3088), 3-year PFS (90.7% vs 97.1%, p = 0.1045), or 5-year PFS (89.2% vs 91.7%, p = 0.4676). The collected data were insufficient to evaluate PBT in NGGCTs.

conclusionPBT and XRT showed comparable survival outcomes in germinoma. Further research is required to explore PBT's potential benefits in preserving cognitive function or reducing secondary cancers.

Indexed as

Central Nervous System NeoplasmsNeoplasms, Germ Cell and EmbryonalProton TherapyX-Ray TherapyChildHumansMaleGerm cell tumorGerminomaMeta-analysisProton beam therapyRadiotherapy

Identifiers

PMID40839232
PMCPMC12474648

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.