ArticleJournal of psychopathology and clinical science2025
Binge drinking trajectories across adolescence and early adulthood: Associations with genetic influences for dual-systems impulsive personality traits, alcohol consumption, and alcohol use disorder.
Alex P Miller, Kellyn M Spychala, Wendy S Slutske, Kim Fromme, Ian R Gizer
Article in Journal of psychopathology and clinical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Alex P MillerDepartment of Psychiatry, Indiana University School of Medicine.ORCID 0000-0001-9163-8947
Kellyn M SpychalaDepartment of Psychological Sciences, University of Missouri.
Wendy S SlutskeDepartment of Family Medicine and Community Health, Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health.
Kim FrommeDepartment of Psychology, University of Texas.
Ian R GizerDepartment of Psychological Sciences, University of Missouri.
Funding
Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VII Core ProjectU01AG071448 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT A HUMMER · 2021 to 2026
$40.2M
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia ProjectU01AG071450 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AIELLO, ALLISON E, HUMMER, ROBERT A · 2021 to 2025
$16.2M
Transdisciplinary Training in Addictions ResearchT32DA015035 · NIDA · WASHINGTON UNIVERSITY · PI Leopoldo J Cabassa, Patricia A Cavazos-Rehg · 2002 to 2026
$5.3M
Alcohol and Behavioral Risks Throughout CollegeR01AA013967 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI FROMME, KIM · 2003 to 2009
$3.3M
Pathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental StudyR01AA018333 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M, KENDLER, KENNETH SEEDMAN · 2010 to 2014
$2.8M
Genetic Mechanisms of Change in Trajectories of Drinking and Deviant BehaviorsR01AA020637 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI FROMME, KIM · 2012 to 2016
$2.3M
Neurogenetic influences linking impulsive personality traits and alcohol use disorder progression across developmentK01AA031724 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI Alex Parker Miller · 2024 to 2026
$548k
Relations between alcohol use, aggression, executive function, and ADHD: a genetic analysisF31AA029948 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI SPYCHALA, KELLYN M · 2022 to 2023
$94k
Multivariate analyses of polygenic risk for impulsivity and alcohol use: A study of longitudinal trajectories of binge drinking in emerging adulthoodF31AA027957 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI MILLER, ALEX PARKER · 2019 to 2022
Binge drinking is a relatively common pattern of alcohol use among youth with normative trajectories peaking in emerging and early adulthood. Frequent binge drinking is a critical risk factor not only for the development of alcohol use disorders (AUDs) but also for increased odds of alcohol-related injury and death and thus constitutes a significant public health concern. Changes in binge drinking across development are strongly associated with individual differences and changes in impulsive personality traits, which have been hypothesized as intermediate phenotypes associated with genetic risk for heavy alcohol use and AUD. The current study examined the extent to which genetic influences underlying dual-systems impulsive personality traits (i.e., top-down [lack of self-control] and bottom-up [sensation seeking and urgency] constructs), alcohol consumption, and AUD are uniquely associated with longitudinal changes in binge drinking and intoxication frequency across adolescence and early adulthood. Associations were tested using conditional latent growth curve polygenic score (PGS) models in three independent longitudinal samples (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Binge drinking trajectories across adolescence and early adulthood: Associations with genetic influences for dual-systems impulsive personality traits, alcohol consumption, and alcohol use disorder. · full record | Socratic