ArticlePloS one2025
Nonlinear association between stress hyperglycemia ratio and severe consciousness disorder in acute ischemic stroke: A MIMIC retrospective analysis.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Systemic immune-inflammation index, stress hyperglycemia ratio and triglyceride-glucose index in acute ischemic stroke: an integrated inflammation-stress-metabolism perspective.Frontiers in neurology · 2026Review
- Association between stress hyperglycemia ratio and 28-day all-cause mortality in critically ill atrial fibrillation patients: a retrospective cohort study based on the MIMIC-IV database.Journal of thoracic disease · 2025Article
- DIFFERENTIAL METABOLIC AND INFLAMMATORY RESPONSES TO ACUTE HYPERGLYCAEMIA IN ISCHAEMIC STROKE: IMPLICATIONS FOR DIABETES STRATIFICATION AND EARLY PROGNOSTICATION.Acta endocrinologica (Bucharest, Romania : 2005)Article
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3 authors.
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Abstract
backgroundThe stress hyperglycemia ratio (SHR) has been extensively studied; however, its association with severe consciousness disorder (Glasgow Coma Scale [GCS] ≤ 8) in patients with acute ischemic stroke (AIS) remains unclear. This study aimed to evaluate the association between SHR and GCS ≤ 8 in AIS as well as its relationship with long-term mortality.
methodsThis retrospective cohort study based on the MIMIC database. The primary outcome was GCS ≤ 8, and the secondary outcome was long-term mortality. The Cox proportional risk model was used to evaluate the relationship between SHR and outcome, and the restricted cubic spline (RCS) method was used to explore the potential nonlinear relationship between SHR and outcome. In addition, Kaplan-Meier curves were used to assess the differences between SHR levels and the incidence of each outcome.
resultsIn this study, the overall incidence of GCS ≤ 8 and long-term mortality were 8.10% and 28.75%, respectively. Multivariate Cox regression analysis showed that SHR was associated with GCS ≤ 8 (HR = 1.52, 95%CI: 1.09-2.14, P = 0.015) and long-term mortality (HR = 1.32, 95%CI: 1.07-1.61, P < 0.0001), and RCS analysis showed a significant non-linear relationship between SHR and GCS ≤ 8 (P for non-linear <0.001), and an approximately linear relationship with long-term mortality (P for non-linear = 0.149). The Kaplan-Meier curve further confirmed that the incidence of GCS ≤ 8 and long-term mortality were significantly higher in patients with high SHR than in those with medium and low SHR (log-rank P < 0.001).
conclusionsElevated SHR was associated with GCS ≤ 8 and long-term mortality in patients with AIS, with a nonlinear relationship for GCS ≤ 8. Further studies are required to confirm these results.
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