GuidelineThe Lancet. Infectious diseases2026
A clinical practice guideline for tuberculous meningitis.
Erratum issuedAbstract readSystematic ReviewPractice Guideline
In one paragraph
Guideline in The Lancet. Infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- The Dephospho-CoA Kinase ofACS omega · 2026Article
- Risk Factors for Poor Neurological Outcomes at Discharge in Tuberculous Meningitis: Disease Severity, Host Factors, and Drug Therapy.Tropical medicine and infectious disease · 2026Article
- Etiologic diagnosis of suspected tuberculous meningitis by multiplex PCR of cerebrospinal fluid.Journal of clinical microbiology · 2026Article
- Management ofOpen forum infectious diseases · 2026Article
- Metabolic insights into the pathophysiology of tuberculous meningitis in FFPE postmortem human brain tissue.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Host-directed treatments for tuberculous meningitis utilizing a multi-platform approach across mouse and human models.Nature communications · 2026Article
- Incidental Papilledema Revealing Neurotuberculosis: A Case Report of a Diagnostic Challenge.Diagnostics (Basel, Switzerland) · 2026Article
- Ischaemia in tuberculous meningitis: update on pathophysiology, clinical predictors and management.Current opinion in infectious diseases · 2026Review
- Article
- The Utility of a Three-gene Host Response to Discriminate Tuberculous Meningitis From Other Infections in Children.The Pediatric infectious disease journal · 2026Article
- Host-directed treatments for tuberculous meningitis: A multi-platform approach across mouse and human models.Research square · 2026Article
- Diagnosis of Tuberculous Meningitis: Integrating Clinical Assessment and Molecular Diagnostics.Diagnostics (Basel, Switzerland) · 2026Review
- Clinical characteristics of childhood tuberculous meningitis and risk factors for severe neurological sequelae disaggregated by age group.BMC infectious diseases · 2026Article
- Machine learning models based on laboratory data: new insight into the differential diagnosis of tuberculous and viral meningitis.Frontiers in cellular and infection microbiology · 2026Article
- Insights from LC-MS-based cerebrospinal fluid metabolomics in tuberculous meningitis.Frontiers in molecular biosciences · 2026Article
- Case Report: extensive leptomeningeal metastasis from gastric cancer presenting with hearing impairment.Frontiers in oncology · 2026Article
- Host- and pathogen-related determinants of pulmonaryEuropean respiratory review : an official journal of the European Respiratory Society · 2026Review
- Automated machine learning model to predict anti-tuberculosis drug-induced liver injury in patients with tuberculous meningitis.Frontiers in pharmacology · 2026Article
- PPD skin test positivity and in-hospital mortality across age groups in non-HIV tuberculous meningitis: a retrospective cohort study.Frontiers in neurology · 2026Article
- Integrating metagenomics, transcriptomics, and molecular docking to reveal core gene biomarkers and gut microbiota regulatory mechanisms in tuberculous meningitis.Frontiers in immunology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
33 authors.
Joseph DonovanOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: jdonovan@oucru.org.
Fiona V CresswellDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK; Global Health and Infection, Brighton and Sussex Medical School, Brighton, UK; Medical Research Council Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Nakiwogo Road, Entebbe, Uganda.
Elizabeth W TuckerDepartment of Anesthesiology and Critical Care Medicine, Division of Pediatric Anesthesiology and Critical Care Medicine, John Hopkins University School of Medicine, Baltimore, MD, USA; Center for Tuberculosis Research, John Hopkins University School of Medicine, Baltimore, MD, USA; Center for Infection and Inflammation Imaging Research, John Hopkins University School of Medicine, Baltimore, MD, USA.
Angharad G DavisThe Francis Crick Institute, London, UK; Wellcome Discovery Research Platforms in Infection, Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa; Queen Mary and Barts Tuberculosis Centre, Queen Mary University London, London, UK.
Ursula K RohlwinkDivision of Neurosurgery, Department of Surgery, Neuroscience Institute, University of Cape Town, Observatory, South Africa.
Julie HuynhOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford, UK.
Regan SolomonsDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
James A SeddonDesmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Department of Infectious Diseases, Imperial College London, London, UK.
Nathan C BahrDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Arjan van LaarhovenDepartment of Internal Medicine, Radboudumc, Nijmegen, Netherlands.
Suzanne T AndersonMRC Clinical Trials Unit, University College London, London, UK.
Sanjay K JainCenter for Tuberculosis Research, John Hopkins University School of Medicine, Baltimore, MD, USA; Center for Infection and Inflammation Imaging Research, John Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pediatrics, John Hopkins University School of Medicine, Baltimore, MD, USA.
Felicia C ChowDepartment of Neurology and Department of Infectious Diseases, University of California, San Francisco, CA, USA.
Sophie PattisonUCL Library Services, Library, Culture, Collections and Open Science (LCCOS), University College London, London, UK.
James E ScrivenDepartment of Microbes, Infection & Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Gabriela SinghDivision of Neurosurgery, Department of Surgery, Neuroscience Institute, University of Cape Town, Observatory, South Africa.
Rob E AarnoutseDepartment of Pharmacy, Radboudumc, Nijmegen, Netherlands.
Jan-Willem C AlffenaarInstitute for Infectious Diseases and Sydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Westmead Hospital, Department of Pharmacy, Westmead, NSW, Australia.
Sofiati DianDepartment of Neurology and Research Center for Care and Control of Infectious Disease, Faculty of Medicine, Universitas Padjadjaran and Hasan Sadikin Hospital, Bandung, Indonesia.
Abi ManeshDepartment of Infectious Diseases, Christian Medical College, Vellore, India.
Robin Basu RoyQueen Mary and Barts Tuberculosis Centre, Queen Mary University London, London, UK.
Varinder SinghNational Center for Excellence in Pediatric Tuberculosis, Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, Bangla Sahib Marg, New Delhi, India.
Ronald van ToornDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Caryn M UptonTASK Clinical Research Centre, Cape Town, South Africa.
Reinout van CrevelCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford, UK; Department of Internal Medicine, Radboudumc, Nijmegen, Netherlands.
Kelly E DooleyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Diana GibbMRC Clinical Trials Unit, University College London, London, UK.
David MeyaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Robert J WilkinsonThe Francis Crick Institute, London, UK; Wellcome Discovery Research Platforms in Infection, Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa; Department of Infectious Diseases, Imperial College London, London, UK.
Ewelina RogozińskaMeta-Analysis Group, University College London, London, UK.
Usha K MisraTS Misra Medical College, Apollo Medics Super Specialty Hospital and Vivekanand Polyclinic and Institute of Medical Sciences, Lucknow, India.
Anthony FigajiDivision of Neurosurgery, Department of Surgery, Neuroscience Institute, University of Cape Town, Observatory, South Africa.
Guy E ThwaitesOxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford, UK.
Funding
ULTIMATER01AI145781 · NIAID · STICHTING RADBOUD UNIVERSITEIT · PI THWAITES, GUY, VAN CREVEL, REINOUT · 2019 to 2023
$4.4MPreclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0MMeasuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8MDetermining the performance and accuracy of SILVAMP TB LAM and cost-effectiveness of diagnostic testing for TB meningitis.R01AI170158 · NIAID · UNIVERSITY OF MINNESOTA · PI Nathan Bahr · 2022 to 2026
$3.5MAdvancing Apoptosis-Inducing Agents as Host-Directed Therapy for TBR01AI186308 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HAMACHER-BRADY, ANNE, JAIN, SANJAY K · 2025 to 2025
$2.9MINTERCEPTR01AI165721 · NIAID · STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM I.O. · PI Guy Thwaites, Reinout Van Crevel · 2022 to 2026
$2.7MPro-apoptotic Drugs as Host-Directed Treatments for Pulmonary Tuberculosis”R01AI190038 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sanjay K Jain · 2025 to 2026
$1.6MNovel Diagnostic Development for TB Meningitis and HistoplasmosisK23NS110470 · NINDS · UNIVERSITY OF MINNESOTA · PI BAHR, NATHAN · 2019 to 2023
$1.0MNovel Imaging and host-directed therapy in pediatric CNS TBK08AI139371 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TUCKER, ELIZABETH WINANS · 2019 to 2023
$994kENLIGHTEN (ENgaging Leaders In Global and local HealTh Equity in Neurology)T32NS131126 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Felicia C. Chow, BRUCE OVBIAGELE · 2024 to 2026
$849kCerebral Hemodynamics and Stroke in HIV-associated TB Meningitis.R21NS134516 · NINDS · UNIVERSITY OF MINNESOTA · PI ABASSI, MAHSA, MUSUBIRE, ABDU KISEKKA · 2023 to 2024
$353kPharmacokinetics and tolerability of adjunctive linezolid for the treatment of tuberculous meningitisR21TW011035 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, FELICIA C. · 2018 to 2019
$322kFIC NIH HHS R21 TW011035Medical Research Council CC2112NIAID NIH HHS K08 AI139371NIAID NIH HHS R01 AI145435NIAID NIH HHS R01 AI145781NIAID NIH HHS R01 AI153349NIAID NIH HHS R01 AI165721NIAID NIH HHS R01 AI170158NIAID NIH HHS R01 AI186308NIAID NIH HHS R01 AI190038NINDS NIH HHS K23 NS110470NINDS NIH HHS R21 NS134516NINDS NIH HHS T32 NS131126Wellcome Trust
Abstract
Tuberculous meningitis is the most severe form of tuberculosis, causing death or disability in around half of those affected. There are no up-to-date international guidelines defining its optimal management. Therefore, the Tuberculous Meningitis International Research Consortium conducted a systematic review of available evidence to address key management questions and to develop practice guidance. The consortium includes representatives from India, Indonesia, South Africa, Uganda, Viet Nam, Australia, the Netherlands, the UK, and the USA. Questions were developed using the Population, Intervention, Comparator, Outcome (PICO) format for tuberculous meningitis diagnosis, anti-tuberculosis chemotherapy, adjunctive anti-inflammatory therapy, and neurocritical and neurosurgical care. A Grading of Recommendations, Assessment, Development and Evaluations approach was used to assess the certainty (or quality) of evidence and establish the direction and strength of recommendations for each PICO-based question. We provide evidence-based recommendations for the optimal treatment and diagnosis of tuberculous meningitis, alongside expert opinion. We expose substantial knowledge and evidence gaps, thereby highlighting current research priorities.
Indexed as
Antitubercular AgentsPractice Guidelines as TopicTuberculosis, MeningealHumansAntitubercular Agents
Identifiers
What Socratic holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.