ArticleContemporary clinical trials2025
Community-clinic partnership to address social needs and improve colorectal cancer screening outcomes: The PRIME stepped-wedge study.
Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUS colorectal cancer screening rates are suboptimal, particularly among Latino populations and patients served by federally qualified health centers (FQHCs). PRIME is a two-phased study to test effectiveness of a multi-component program to address patient social needs and improve colorectal cancer screening and follow-up in neighborhoods served by our partnering FQHC.
methodsPRIME is a modified stepped-wedge study involving health-center patients in 12 neighborhoods in Southern California, followed by a scale-up study involving four additional health centers/neighborhoods. Eligible adults are ages 45-64, due for colorectal cancer screening, with a health center clinic visit in the previous 6 months. The intervention combines: (1) phone-based advance notification, a mailed FIT, and text messages with links to a short animated instructional video on FIT completion, (2) patient navigation for addressing patients' social needs, and (3) neighborhood-level events to raise awareness about the need for colorectal cancer screening.
resultsRecruitment for Phase I began in July 2024. Primary effectiveness outcome is receipt of any colorectal cancer screening within 6 months; primary implementation outcome is clinic-level and organizational-level rates of program delivery, by component (e.g., mailed FIT, social needs navigation, community events). Phase II scale-up activities will: use webinars, train-the-trainer workshops, and collaborative learning activities; and will assess adoption of and adaptations to the multi-component program.
conclusionThis study will test the effectiveness, implementation, and scale-up of a multi-component video text message and social needs navigation program to improve colorectal cancer screening uptake in neighborhoods served by our partnering FQHC and community-based organizations.
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