Evidence map›Paper›PMID 40840920›Full record

ArticleRenal failure2025

Mechanism of

Yuhe Yan, Honghong Shi, Yue Li, Xing Wan, Jinxin Li, Lihua Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuhe YanDivision of Nephrology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Honghong ShiDivision of Nephrology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Yue LiDivision of Nephrology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Xing WanDivision of Nephrology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Jinxin LiDivision of Nephrology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Lihua WangDivision of Nephrology, The Second Hospital of Shanxi Medical University, Taiyuan, China.ORCID 0000-0003-2741-7765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough

methodsActive compounds of

resultsThe top 10 core targets were identified, namely PPARG, AKT1, EGFR, STAT3, CASP3, PPARA, ICAM1, PTGS2, SRC, and MMP9. Enrichment analysis revealed that the primary pathways involving these targets including prolactin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, relaxin signaling pathway, VEGF signaling pathway, and FoxO signaling pathway. Molecular docking demonstrated that mandenol exhibited a strong binding affinity toward EGFR domain, and wallichilide displayed pronounced binding affinity toward AKT1, EGFR, STAT3, and PTGS2 domains. Additionally, myricanone and senkyunone also showed strong binding affinity for AKT1, EGFR, CASP3, STAT3, and PTGS2 domains.

conclusionsThis study revealed the potential multi-component and multi-target mechanisms of

Indexed as

Diabetic NephropathiesDrugs, Chinese HerbalHumansMedicine, Chinese TraditionalMolecular Docking SimulationNetwork PharmacologyRhizomeSignal Transductionchuanxiong rhizome preparationDrugs, Chinese HerbalDKDmechanismnetwork pharmacologyRhizoma Chuanxiong

Identifiers

PMID40840920
PMCPMC12372503

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.