Evidence map›Paper›PMID 40841108›Full record

ArticleJACC. CardioOncology2025

Ischemic Injury Drives Nascent Tumor Growth Via Accelerated Hematopoietic Aging.

Alexandra A C Newman, José Gabriel Barcia Durán, Richard Von Itter, Jessie M Dalman, Brian Lim, Morgane Gourvest, Tarik Zahr, Kristin M Wang, Tracy Zhang, Noah Albarracin and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. CardioOncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Alexandra A C NewmanCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA. Electronic address: https://twitter.com/aacnewman13.
José Gabriel Barcia DuránCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Richard Von ItterCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Jessie M DalmanCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA; Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Brian LimCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Morgane GourvestCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Tarik ZahrCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Kristin M WangCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Tracy ZhangCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Noah AlbarracinCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Whitney G RubinCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Fazli K BozalCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Kory J LavineCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA.
Chiara GiannarelliCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA; Department of Pathology, New York University Grossman School of Medicine, New York, New York, USA.
Michael GildeaCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Coen van SolingenCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Kathryn J MooreCardiovascular Research Center, Department of Medicine, New York University Langone Health, New York, New York, USA; Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA; Department of Cell Biology, New York University Grossman School of Medicine, New York, New York, USA. Electronic address: kathryn.moore@nyulangone.org.

Funding

Resolving Macrophage Inflammation in Atherosclerotic Plaques and Other Sites in Insulin ResistanceP01HL131481 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANN MARIE SCHMIDT · 2017 to 2026
$27.3M
Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3M
Dissecting the role of CD8+ T cells in atherosclerosisR01HL153712 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GIANNARELLI, CHIARA · 2020 to 2024
$3.3M
The role of immune-responsive gene 1 and itaconate in atherosclerotic diseaseR01HL172365 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KATHRYN J MOORE · 2024 to 2026
$2.3M
Long noncoding RNA regulation of Atherosclerotic Cardiovascular DiseaseR01HL172335 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KATHRYN J MOORE · 2024 to 2026
$2.2M
NHLBI NIH HHS P01 HL131481NHLBI NIH HHS R01 HL153712NHLBI NIH HHS R01 HL172335NHLBI NIH HHS R01 HL172365NHLBI NIH HHS R35 HL161185
6 · The paper itself

Abstract

backgroundPatients with peripheral artery disease have an increased risk of cancer development. Aging-associated changes in hematopoietic stem and progenitor cells (HSPCs), including inflammation and increased myelopoiesis, are implicated in both cardiovascular disease and cancer, but their contributions to cardiovascular disease-driven tumor progression are unclear.

objectivesThis study sought to study tumor growth after peripheral ischemia and consequent changes within the HSPC bone marrow compartment to uncover mechanisms through which altered hematopoiesis promotes cancer.

methodsMammary cancer (E0771) growth was monitored in C57BL/6J mice after hind limb ischemia (HLI) or sham surgery. The tumor immune microenvironment, circulatory immune cells, and HSPC compartment were assessed by flow cytometry. Next-generation single-cell RNA and assay for transposase-accessible chromatin sequencing of bone marrow progenitors was performed to assess the distinct and synergistic transcriptomic and epigenetic changes of cancer and peripheral ischemia. The functional impact on tumor progression and persistence of ischemia-induced epigenetic reprogramming of HSPCs and their myeloid progeny was examined by bone marrow transplantation.

resultsPeripheral ischemia increased monocyte and neutrophil output at the expense of lymphocytes, driven by a shift toward CD150

conclusionsPeripheral ischemia enhances inflammaging of hematopoietic stem cells and long-lasting alterations to antitumoral immunity, accelerating breast tumor growth.

Indexed as

bone marrow transplantationbreast cancercardiovascular diseaseepigeneticsimmune-oncologyinflammaginginflammationischemiamyelopoiesisperipheral arterial diseaseperipheral vascular diseasereverse cardio-oncology

Identifiers

PMID40841108
PMCPMC12441627

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.