Evidence map›Paper›PMID 40841483›Full record

ArticleCell death and differentiation2026

BRCA1 and BRCA2 gene expression: p53- and cell cycle-dependent repression requires RB and DREAM.

Marianne Quaas, Robin Kohler, Lukas Nöltner, Louisa F Schmidbauer, Sigrid Uxa, Gerd A Müller, Kurt Engeland

Abstract read
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marianne Quaas *Molecular Oncology, Faculty of Medicine, University of Leipzig, Leipzig, Germany.ORCID 0000-0002-2781-1968
Robin Kohler *Molecular Oncology, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Lukas NöltnerMolecular Oncology, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Louisa F SchmidbauerMolecular Oncology, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Sigrid UxaMolecular Oncology, Faculty of Medicine, University of Leipzig, Leipzig, Germany.ORCID 0000-0002-8183-2153
Gerd A MüllerMolecular Oncology, Faculty of Medicine, University of Leipzig, Leipzig, Germany.ORCID 0000-0002-4967-2487
Kurt EngelandMolecular Oncology, Faculty of Medicine, University of Leipzig, Leipzig, Germany. engeland@medizin.uni-leipzig.de.ORCID 0000-0003-3525-0440

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 424870812 (EN 218/11-1 and EN 218/11-2)Deutsche Forschungsgemeinschaft (German Research Foundation) project number 277046125
6 · The paper itself

Abstract

BRCA1 and BRCA2 proteins are crucial for DNA repair through homologous recombination (HR), which predominantly takes place during S and G

Indexed as

BRCA1 ProteinBRCA2 ProteinCell CycleKv Channel-Interacting ProteinsRepressor ProteinsRetinoblastoma ProteinTumor Suppressor Protein p53Cell Line, TumorCyclin-Dependent Kinase Inhibitor p21DNA DamageDNA RepairDown-RegulationHumansBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanCyclin-Dependent Kinase Inhibitor p21Kv Channel-Interacting ProteinsRepressor ProteinsRetinoblastoma ProteinTumor Suppressor Protein p53

Identifiers

PMID40841483
PMCPMC12811384

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.