ArticleJournal of human genetics2025
Polygenic risk score as a tool to predict gestational weight gain and gestational diabetes among pregnant women in Taiwan.
Article in Journal of human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication influenced by pre-pregnancy overweight or obese and high gestational weight gain (GWG). This study investigated the impact of body mass index (BMI)-related genetic variants on GWG and GDM risk among Taiwanese women. A case-control study of 3875 pregnant women included 3162 with GDM based on oral glucose tolerance tests and 2483 with GWG data. A genome-wide association study of 71,848 women identified BMI related genetic variants, and a polygenic risk score for BMI (PRS_BMI) was calculated. PRS_BMI was positively associated with GWG (R² = 0.010, P < 0.001). The odds ratio (ORs) for high GWG and GDM per standard deviation increase in PRS_BMI were 2.28 (95% CI = 2.03-2.55, P < 0.001) and 1.34 (95% CI = 1.24-1.45, P < 0.001), respectively. Stratified analyses indicated stronger associations in women with BMI < 25 kg/m², while weaker associations were observed in those with BMI ≥ 25 kg/m². These findings suggest PRS_BMI could be used to identify women at higher risk for excessive GWG and GDM, aiding in early monitoring and targeted risk-reduction strategies.
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