Evidence map›Paper›PMID 40841919›Full record

ArticleBMC research notes2025

Phenotypic and genotypic relationships between Shigella species and Escherichia coli O37:H10 isolates in Addis Ababa, Ethiopia.

Basha Ayele, Zeleke Mekonnen, Tesfaye Sisay Tessema, Dawit Hailu Alemayehu, Kalkidan Melaku, Shewki Moga, Maeruf Fetu Nassir, Abaysew Ayele, Adane Mihret, Getenet Beyene

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Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Basha AyeleDepartment of Medical Laboratory Science, College of Health Science and Medicine, Dilla University, P.O.Box 419, Dilla, Ethiopia. ayelebasha@gmail.com.
Zeleke MekonnenSchool of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.
Tesfaye Sisay TessemaInstitute of Biotechnology, Addis Ababa University, Addis Ababa, Ethiopia.
Dawit Hailu AlemayehuArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Kalkidan MelakuArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Shewki MogaEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Maeruf Fetu NassirArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Abaysew AyeleArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Adane MihretArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Getenet BeyeneSchool of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate the genotypic and phenotypic differences between Shigella species and E. coli O37:H10, as well as their antimicrobial resistance (AMR) and virulence factors, in children aged under five with diarrhea in Addis Ababa, Ethiopia.

resultsUsing whole genome sequencing (WGS), all 28 S. sonnei identified with antisera were also verified as S. sonnei, while all nine isolates of S. flexneri were found to be E. coli O37:H10. One S. flexneri sample, identified serologically, was excluded from WGS analysis because of low genome coverage. Most resistant genes were associated with beta-lactam and trimethoprim drugs. All S. sonnei isolates had genes that encoded blaEC-8 and blaZEG-1. The E. coli O37:H10 had the Extended-spectrum beta-lactamase (ESBL) blaEC-15 for cephalosporins, blaMIX-2, and blaMIX-6 for penicillin. In contrast to S. sonnei, the most prevalent plasmid type in E. coli O37:H10 isolates was IncFII, while virulence genes like gad were frequently detected. Composite transposons, such as cn_43599_IS621 and cn_3785_IS3, were detected in all S. sonnei and E. coli O37:H10. Generally, the study highlighted a significant discrepancy between phenotypic and genotypic AMR, as well as variations in serotypes and phylogenetic relationships with global isolates.

Indexed as

Dysentery, BacillaryEscherichia coliEscherichia coli InfectionsShigellaShigella flexneriShigella sonneiAnti-Bacterial Agentsbeta-LactamasesChild, PreschoolDiarrheaDrug Resistance, BacterialDrug Resistance, Multiple, BacterialEthiopiaGenotypeHumansInfantAnti-Bacterial Agentsbeta-LactamasesVirulence FactorsAddis AbabaE. coli O37:H10Shigella speciesWGS

Identifiers

PMID40841919
PMCPMC12372388

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.