Evidence mapPaperPMID 40842476Full record

ArticleFrontiers in cardiovascular medicine2025

Predictive value of atherogenic index of plasma in combination with diagonal earlobe crease in coronary heart disease.

Ruoling Guo, Mingliang Sun, Huihui Yang, Jie Dou, Jie Gao, Tong Liu, Fei Cheng, Donglei Luo

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Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ruoling Guo *Department of Chengde Medical University, Chengde, Hebei, People's Republic of China.
Mingliang Sun *Department of Chengde Medical University, Chengde, Hebei, People's Republic of China.
Huihui YangDepartment of Chengde Medical University, Chengde, Hebei, People's Republic of China.
Jie DouDepartment of Chengde Medical University, Chengde, Hebei, People's Republic of China.
Jie GaoDepartment of Emergency, Handan City First Hospital, Handan, Hebei, People's Republic of China.
Tong LiuDepartment of Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Fei ChengDepartment of Neurology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, Hebei, China.
Donglei LuoDepartment of Cardiology, Chengde Central Hospital/Second Clinical College of Chengde Medical University, Chengde, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The atherogenic index of plasma (AIP) and diagonal earlobe crease (DELC) are correlated with the incidence of coronary heart disease (CHD). Nevertheless, the role of AIP and DELC in the characterization and prediction of CHD remains underexplored. Methods: This study enrolled a total of 1,378 patients suspected to be indicative of CHD, all of whom were admitted to Chengde Central Hospital between September 2021 and August 2024. Based on coronary angiography (CAG), the cohort was stratified into two groups: the CHD group ( Results: The results showed that AIP and DELC were positively correlated with CHD. Age, gender, hypertension, diabetes mellitus (DM), aspartate aminotransferase (AST), AIP, creatinine (CR), and DELC were independent risk factors for CHD. AIP was correlated with the Gensini score, indicating that as AIP levels rise, the severity of CHD intensifies. A progressive increase in DELC positivity was observed with higher Gensini scores. The diagnostic model for CHD was constructed based on the above risk factors. The area under the curve (AUC) for the integrated application of AIP and DELC was 0.702, highlighting the model's considerable diagnostic efficacy in the identification of CHD. Conclusions: AIP and DELC were independent risk factors for CHD. The combination of the two factors exhibited great predictive value for the diagnosis of CHD.

Indexed as

atherogenic index of plasmacoronary heart diseasediagonal earlobe creasemodelpredict

Identifiers

PMID40842476
PMCPMC12364857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.