Evidence map›Paper›PMID 40842566›Full record

ArticleFrontiers in cellular neuroscience2025

Translocator protein deficiency blocks the ferroptosis of malignant peripheral nerve sheath tumors through glutathione peroxidase 4.

Xiaoli Zhang, Zhuonan Pu, Chun Ran, Xingnan Zhang, Chao Guo, Yuxuan Deng, Jinqiu Liu, Yingdan Chen, Jie Feng, Song Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoli Zhang *Department of Injury and Repair, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Zhuonan Pu *Department of Injury and Repair, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Chun RanChina Ordnance Society, Beijing, China.
Xingnan ZhangDepartment of Injury and Repair, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Chao GuoDepartment of Injury and Repair, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yuxuan DengDepartment of Injury and Repair, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jinqiu LiuDepartment of Injury and Repair, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yingdan ChenDepartment of Injury and Repair, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jie FengDepartment of Injury and Repair, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Song LiuDepartment of Injury and Repair, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive soft tissue sarcoma characterized by high recurrence and poor prognosis, necessitating the search for novel therapeutic targets and strategies. This study investigated the expression of mitochondrial translocator protein (TSPO) in MPNST and its role in regulating ferroptosis. Methods: TSPO expression was analyzed in adjacent non-tumor tissues, benign neurofibromas, and malignant tissues using real-time PCR, western blotting, immunohistochemistry staining. Expression levels of classic ferroptosis markers, including AKR1C1 and FTH1 were assessed. Ferroptosis was evaluated by measuring cell viability, ferroptosis marker levels, and intracellular Fe Results: Compared with adjacent non-tumor tissues and benign neurofibromas, TSPO expression was significantly lower in MPNST specimens. Notably, TSPO expression positively correlated with the classic ferroptosis markers AKR1C1 and FTH1. TSPO-knockdown MPNST cells exhibited significant resistance to ferroptotic cell death. Additionally, biochemical characterization indicated that TSPO deficiency decreased intracellular Fe Conclusion: Our findings revealed that TSPO deficiency inhibited ferroptosis in MPNST cells by upregulating GPX4 antioxidant pathway, suggesting that mitochondrial TSPO-GPX4-ferroptosis axis may be a promising therapeutic target for improving the outcomes of patients with MPNST.

Indexed as

ferroptosisglutathione peroxidase 4lipid peroxidationmalignant peripheral nerve sheath tumortranslocator protein

Identifiers

PMID40842566
PMCPMC12364865

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.