ArticleFrontiers in pediatrics2025
Development of the EPO-Score - a multivariable tool to predict adverse outcome in infants with perinatal asphyxia undergoing therapeutic hypothermia - a retrospective study.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Early outcome prediction in neonates with perinatal asphyxia receiving therapeutic hypothermia (TH) remains difficult. Although several studies have explored prognostic markers and proposed scoring systems, none of these tools has been adopted for routine bedside use to date. The present retrospective study aimed to design an early prognostic outcome score (EPO-Score). The score serves to identify patients at discharge, predicting severe adverse outcomes according to the Griffiths Mental Development Scales (GMDS) with one year. Methods: Perinatal data was collected from 44 infants with perinatal asphyxia who had received therapeutic hypothermia between 2010 and 2020 at the University Hospital Erlangen, Germany. 27 predictive variables were analyzed regarding their prognostic significance. Analysis showed significant correlations between 15 variables and their outcome. Outcome at one year was classified as favorable (GMDS DQ > 78) or severe adverse (DQ < 78, cerebral palsy, or death). We combined related variables into four indices: systemic injury, neurologic, liver and renal damage. A forward-looking step-by-step analysis revealed a model, explaining 62.1% of the variance in the outcome (R Results: A total of 32 (out of 44) infants met the inclusion criteria. 25 infants experienced a favorable outcome, 7 infants a severe adverse outcome. The EPO-Score integrates eight routine predictors. Average EPO-Score among all infants was 11 points (range 0-24). The EPO-Score showed significant association with the developmental outcome at one year of age (R Conclusion: EPO-Score underlines the correlation between the severity of early multi-organ involvement and severe adverse outcome, demonstrating a high predictive value within our study population. Early identification of patients with severe adverse outcome is important for optimizing neurodevelopmental therapies and providing family support. Nevertheless, external validation is required before the score can be implemented in routine clinical care.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.