ArticleTransboundary and emerging diseases2025
Epidemiology and Pathogenicity Analysis Based on Partial Recombinant PRRSV Strains in China.
Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Genetic Diversity, Phylogenetic Lineages, and Antigenic Features of the PRRSV-1 GP5 Gene in China.Microorganisms · 2026Article
- Detection, virus isolation, and phylogenetic analysis of PRRSV2 in China from 2022 to 2025.Porcine health management · 2026Article
- Molecular and pathological characteristics of co-infection with PRRSV-1 and PRRSV-2 recombinant strains in a pig farm in Xinjiang, China.BMC veterinary research · 2026Article
- The updated one-step multiplex RT-qPCR method for PRRSV classical strains, highly pathogenic strains and NADC30-like strains.Frontiers in microbiology · 2026Article
- Reevaluating PRRSV-induced respiratory distress: beyond interstitial pneumonia to pulmonary surfactant dysfunction and airway obstruction.Frontiers in immunology · 2026Article
- Isolation and genetic characterization of a novel recombinant HP-PRRSV strain in Jiangxi Province, China.Frontiers in veterinary science · 2025Article
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Authors and funding
9 authors.
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Abstract
Currently, multiple recombinant variants of porcine reproductive and respiratory syndrome virus (PRRSV) are circulating in China. These variants exhibit differences in pathogenicity. To comprehensively understand the current status of the virus and its recombination patterns, a total of 677 PRRSV strains were used for evolutionary analysis, of which 673 strains were isolated from mainland China. The results indicated that current PRRSV strains in circulation in China are highly complex, with NADC30-like strains having replaced highly pathogenic strain of PRRSV (HP-PRRSV) strains as the dominant strains. An analysis of the patterns and hotspots of PRRSV-2 recombinant strains from 2019 to 2023 revealed two main types: the strains with NADC30 as the primary parent were observed to have recombination hotspots concentrated in the Nsp1, Nsp4 to Nsp9, and ORF2 to ORF6 regions, while recombination frequencies were found to be lower in the Nsp2, Nsp10, and Nsp11 regions. In contrast, the other type of recombinant strain, primarily derived from HP-PRRSV, exhibited recombination hotspots concentrated in the Nsp2 and ORF2 to ORF6 regions, while the recombination frequency in the Nsp8 and Nsp9 regions was relatively low. Further, a comprehensive analysis of the phylogenetic and recombination patterns of four PRRSV strains (ZJ-2021-1, JS-2020-1, GZ-2022-1, and SH-2020-2) indicated variations in genotyping precision among Nsp2, ORF5, and the entire genome. As demonstrated by the results of the animal experiments, there were differences in pathogenicity between ZJ-2021-1 and JS-2020-1. The pathogenicity of the recombinant strain exhibited similar characteristics to its parental skeleton. Our results provided reference data for exploring epidemiological characteristics and pathogenicity of recombinant PRRSV strains.
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