ArticleActa psychiatrica Scandinavica2025
Risk of Dementia in Patients Suffering From Psychosis-A Danish Register-Based Cohort Study.
Article in Acta psychiatrica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Finding risk factors for dementia in patients with schizophrenia: a population-based case-control study.BMC psychiatry · 2026Article
- Risk of Dementia in Patients Suffering From Psychosis-A Danish Register-Based Cohort Study.Acta psychiatrica Scandinavica · 2025Article
- Schizophrenia and dementia across the lifespan: epidemiological links, cognitive trajectories, and the pathophysiological interplay.Frontiers in neurologyReview
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4 authors.
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Abstract
objectiveTo investigate the association of psychosis with subsequent risk of dementia and to explore any impact of age at psychosis onset.
methodsUsing the Danish National health registries, a total of 39,022 patients with a diagnosis of psychosis and a matched sample of 195,109 individuals without psychosis were included in the study. All individuals were born between 1910 and 1959 and were a minimum of 18 years of age in 1969. The risk of being diagnosed with dementia was analyzed using Cox proportional hazard regression with adjustment for sociodemographic variables and alcohol use disorder. Analyses were stratified by age of psychosis onset (< 45/45+ years) and age at follow-up in three categories (60-70, 70-80, and 80 or above).
resultsDuring mean 16.8 years of follow-up, 18,653 (12.55%) of all individuals developed dementia. Patients with psychosis had a higher risk of dementia at all ages of follow-up, with the highest risk estimate at follow-up before age 70 (hazard ratio (HR) adjusted 4.44 CI (4.01-4.91)). However, the risk also varied with age at psychosis onset, being highest at late-onset (adjusted hazard ratio: 5.16 (95% confidence interval: 4.59-5.81)).
conclusionPatients with psychosis had a higher risk of developing dementia than individuals without psychosis. The risk varied with age at psychosis onset and age at follow-up.
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