Evidence map›Paper›PMID 40844182›Full record

Trial reportHealth technology assessment (Winchester, England)2025

Eradication of

C J Hawkey, Anthony J Avery, Carol Ac Coupland, Colin J Crooks, Jennifer S Dumbleton, Fd Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Health technology assessment (Winchester, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01506986 (Helicobacter Eradication to Prevent Ulcer Bleeding in Aspirin Users), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01506986 phase4completednot on this map

Helicobacter Eradication to Prevent Ulcer Bleeding in Aspirin Users: a Large Simple Randomised Controlled Trial

TypeinterventionalSponsorUniversity of NottinghamRan2012 to 2022Enrolled30,024ConditionsGastrointestinal Ulcer Haemorrhage, Bacterial Infection Due to Helicobacter Pylori (H. Pylori)ArmsLansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg, Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Social determinants of health andFrontiers in public health · 2025
    Pooled it
  2. Article
  3. Therapeutic advances and future directions inFrontiers in microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

C J HawkeySimple Trials for Academic Research Unit, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0002-6031-1017
Anthony J AveryCentre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0001-7591-4438
Carol Ac CouplandCentre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0002-2327-3306
Colin J CrooksSimple Trials for Academic Research Unit, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0002-6794-6621
Jennifer S DumbletonSimple Trials for Academic Research Unit, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0001-9099-5555
Fd Richard HobbsNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID 0000-0001-7976-7172
Denise KendrickCentre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0003-3603-6542
Michael MoorePrimary Care Research Centre, University of Southampton, Southampton, UK.ORCID 0000-0002-5127-4509
Clive MorrisTCR Nottingham Ltd, Langley Mill, UK.
Gregory RubinPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-4967-0297
Murray SmithAberystwyth Business School, Aberystwyth University, Aberystwyth, UK.ORCID 0000-0002-5363-4184
Diane StevensonSimple Trials for Academic Research Unit, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0003-3533-1005
HEAT trialists

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Peptic ulcers in patients on aspirin are associated with Methods: The Findings: Between 14 September 2012 and 22 November 2017, 30,166 participants underwent Interpretation: Limitations and future work: Studying subjects already established on aspirin probably contributed to the low event rate. A future study should investigate subjects starting on aspirin when the event rate is higher. Trial registration: This trial is registered as ISRCTN10134725; ClinicalTrials.gov number NCT01506986. Funding: This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 09/55/52) and is published in full in

Indexed as

Anti-Bacterial AgentsAspirinHelicobacter InfectionsHelicobacter pyloriPeptic Ulcer HemorrhageAgedAnti-Ulcer AgentsBreath TestsClarithromycinDrug Therapy, CombinationFemaleHumansLansoprazoleMaleMetronidazoleProportional Hazards ModelsAnti-Bacterial AgentsAnti-Ulcer AgentsAspirinClarithromycinLansoprazoleMetronidazoleASPIRINC13 UREA BREATH TESTCLARITHROMYCINCONSULTATION AND REFERRALDEATHDYSPEPSIAFOLLOW-UP STUDIESGASTROINTESTINAL HAEMORRHAGEHELICOBACTER PYLORIHOSPITALISATIONINTENTION-TO-TREAT ANALYSISLANSOPRAZOLEMETRONIDAZOLEOUTCOMES STUDYPEPTIC ULCERPEPTIC ULCER HAEMORRHAGEPRIMARY CARERANDOMISED CONTROLLED TRIAL

Identifiers

PMID40844182
PMCPMC12434569

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.