ReviewAngewandte Chemie (International ed. in English)2025
Synthesis and Application of Bioactive N-Functionalized Aziridines.
Review in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Photoinduced cobalt-catalyzed enantioconvergent synthesis of 1,3-diamines via aziridine ring-opening addition.Science advances · 2026Article
- Photochemical Cascade Nitrile Activation via a Carbene-Nitrene Relay.Angewandte Chemie (International ed. in English) · 2026Article
- Aziridination-Enabled Structural and Quantitative Lipidomics.Journal of the American Society for Mass Spectrometry · 2026Review
- Aziridination of a Single Carbon Atom in Alkenes via Energy Transfer Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Photocatalyzed Ring Expansion of α-Ketosulfonylaziridines: Ready Access to δ-Sultams.Angewandte Chemie (International ed. in English) · 2026Article
- Direct Aziridine Synthesis from Amines and Styrene Derivatives via a Base-Promoted Oxidative Cascade Reaction.Journal of the American Chemical Society · 2026Article
- Bifunctional Aziridines from Photochemically Generated FSOAngewandte Chemie (International ed. in English) · 2026Article
- Synthesis and Application of Bioactive N-Functionalized Aziridines.Angewandte Chemie (International ed. in English) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Aziridines-three-membered nitrogen heterocycles that engage in strain-accelerated ring opening chemistry-are not common functional groups in bioactive natural products. As such, the discovery and optimization of predictable and general methods for the construction of aziridines is critical to the development, evaluation, and optimization of small molecules that contain aziridines. In this review, we discuss modern synthetic strategies for the construction of aziridines. Synthetic methods are categorized based on the synthetic logic used to assemble the aziridine ring: 1) Addition of nitrene equivalents to olefins, 2) addition of carbene equivalents to imines, and 3) intramolecular cyclization chemistry. Special emphasis is given to methods that allow modular control over the identity of the exocyclic nitrogen valence, which directly impacts the electrophilicity, and thus biological activity, of the resulting aziridines. After describing the state of the art in aziridine synthesis, we discuss established and emerging biological applications of aziridine-containing small molecules, including application as proteomics probes that enable liganding of nonstandard amino acid residues and application in lipidomics. Finally, extant synthetic challenges that must be addressed to realize the full potential of aziridine-based small molecules are described.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.