Evidence map›Paper›PMID 40844207›Full record

ReviewEuropean journal of immunology2025

SOCS Proteins: Key Players in Immune Regulation During SARS-CoV-2 Infection.

Juber Herrera-Uribe, Nigel J Stevenson

Abstract readReview
In one paragraph

Review in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Juber Herrera-UribeViral Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Nigel J StevensonViral Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Funding

Science Foundation Ireland SFI 19/FFP/6483Science Foundation Ireland SFI 20/SPP/3685
6 · The paper itself

Abstract

Suppressor of cytokine signaling (SOCS) proteins are crucial components of the immune response against viral infections. SOCS proteins inhibit cytokine signaling through various mechanisms, such as blocking STAT binding to JAKs and targeting proteins for ubiquitination and degradation. While these proteins maintain immune balance by suppressing excessive inflammatory responses, many viruses, including SARS-CoV-2, exploit SOCS proteins to evade host immunity. In consequence, understanding their modulatory functions in viral disease has become increasingly relevant. Therefore, this review aims to describe and discuss studies involving SOCS expression data in COVID-19 and their potential modulation as a valuable use for therapeutic strategies.

Indexed as

COVID-19SARS-CoV-2Suppressor of Cytokine Signaling ProteinsAnimalsHumansSignal TransductionSuppressor of Cytokine Signaling ProteinsCOVID‐19cytokine signalingSOCS proteinsviral infections

Identifiers

PMID40844207
PMCPMC12372453

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.